Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-aging Activity of Aralia Cordata Thunb. by Inhibiting Oxidized Low-dencity Lipoprotein Production in Rats

  • Hyun, Min-Kyung (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Ji-Cheon (Department of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • Published : 2007.12.25
Download PDF
⟨ Previous Next ⟩

Abstract

Aralia cordata Thunb. (Araliaceae, ACT) is an remarkable herbal plant that has been widely used in traditional oriental medicine for the treatment of inflammatory diseases and cardiovascular disorders. In this study, we have established a vascular aging model in rats by orally administrating excessive vitamin $D_2$ (500,000 IU/kg/day) for 4 days followed by feeding high cholesterol diet for 16 weeks and then rats were randomly divided into control group, high cholesterol diet (HCD) group, HCD+ACT (30 mg/kg) and HCD+ACT (60 mg/kg) group. ACT (30, 60) significantly reduced total cholesterol (TC) content compared with HCD, but no significant differences in the serum lipids. Secondly, we measured the serum levels of Oxidized Low-dencity Lipoprotein (OxLDL) and malondialdehyde (MDA) in order to further investigate the anti-vascular aging mechanism of ACT. The results, ACT (30, 60) treatments decreased OxLDL, MDA　content　and increased Cu/Zn superoxide dismutase activity compared with HCD treatments. The results suggested that ACT inhibited OxLDL production rather than serum lipids lowering and that ACT could be used as potential anti-atherosclerotic agent in aged cells.

Keywords

References

  1. Chang, H.M., But, P.P.H. Pharmacology and Applications of Chinese Materials Medica. Singapore:World Scientific Publishing Co. pp 255-268, 605, 1986
  2. Dang, N.H., Zhang, X., Zheng, M., Son, K.H., Chang, H.W., Kim, H.P., Bae, K., Kang, S.S. Inhibitory constituents against cyclooxygenases from Aralia cordata Thunb. Archives of Pharmacal Research 28(1):28-33, 2005 https://doi.org/10.1007/BF02975131
  3. Yahara, S., Ishida, M., Yamasaki, K., Tanaka, O., Mihashi, S. Minor diterpenes of Aralia cordata Thunb: 17-hydroxy-ent-kaur-15-en-19-oic acid and grandifloric acid. Chem Pharm Bull (Tokyo). 22(7):1629-1631, 1974 https://doi.org/10.1248/cpb.22.1629
  4. Cai, G.J., Miao, C.Y., Xie, H.H., Lu, L.H., Su, D.F. Arterial baroreflex dysfunction promotes atherosclerosis in rats. Atherosclerosis. 183: 41-47, 2005 https://doi.org/10.1016/j.atherosclerosis.2005.03.037
  5. Galle, J., Hansen-Hagge, T., Wanner, C., Seibold, S. Impact of oxidized low density lipoprotein on vascular cells. Atherosclerosis. 185: 219-226, 2006 https://doi.org/10.1016/j.atherosclerosis.2005.10.005
  6. Anselmi, M., Garbin, U., Agostoni, P., Fusaro, M., Pasini, A.F., Nava, C., Keta, D., Turri, M., Zardini, P., Vassanelli, C., Lo Cascio, V., Cominacini, L. Plasma levels of oxidized-low-density lipoproteins are higher in patients with unstable angina and correlated with angiographic coronary complex plaques. Atherosclerosis. 185: 114-120, 2006 https://doi.org/10.1016/j.atherosclerosis.2005.05.020
  7. Dominguez-Rodriguez, A., Abreu-Gonzalez, P., Garcia-Gonzalez, M., Ferrer-Hita, J., Vargas, M., Reiter, R.J. Elevated levels of oxidized low-density lipoprotein and impaired nocturnal synthesis of melatonin in patients with myocardial infarction. Atherosclerosis. 180: 101-105, 2005 https://doi.org/10.1016/j.atherosclerosis.2004.11.003
  8. Park, W.H., Shin, S.S., Lee, Y.C., Kim, C.H. The inhibitory effects of Silso-San-Gami on atherosclerosis in KHC rabbits. Thrombosis Res. 113: 235-241, 2004 https://doi.org/10.1016/j.thromres.2004.03.011
  9. Moghadasian, M.H. Experimental atherosclerosis: a historical overview. Life Sci. 70: 855-865, 2002 https://doi.org/10.1016/S0024-3205(01)01479-5
  10. Liu, G.T., Zhang, T.M., Wang, B.E., Wang, Y.W. Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochemical Pharmacology. 43(2):147-152, 1992 https://doi.org/10.1016/0006-2952(92)90271-J
  11. Kleemann, R., Princen, H.M., Emeis, J.J., Jukema, J.W., Fontijn, R.D., Horrevoets, A.J., Kooistra, T., Havekes, L.M. Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in $APOE^*3$-Leiden transgenic mice: evidence for antiinflammatory effects of rosuvastatin. Circulation. 108: 1368-1374, 2003 https://doi.org/10.1161/01.CIR.0000086460.55494.AF
  12. Yeung, A.C., Tsao, P. Statin therapy: beyond cholesterol lowering and antiinflammatory effects. Circulation. 105: 2937-2938, 2002 https://doi.org/10.1161/01.CIR.0000023397.12047.03
  13. Meisinger, C., Baumert, J., Khuseyinova, N., Loewel, H., Koenig, W. Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population. Circulation. 112: 651-658, 2005 https://doi.org/10.1161/CIRCULATIONAHA.104.529297