Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Neuroprotective Effect of Heyneanol A from the roots of vitis amurensis Rup

왕머루포도 뿌리에서 분리한 heyneanol A의 신경보호효과

  • Hwang, Hwa-Soo (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Namgung, Mi-Ae (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Lee, Eun-Ok (College of Oriental Medicine, Kyunghee University) ;
  • Shim, Bum-Sang (College of Oriental Medicine, Kyunghee University) ;
  • Ahn, Kyoo-Seok (College of Oriental Medicine, Kyunghee University) ;
  • Kim, Sung-Hoon (Graduate School of East-West Medical Science, Kyunghee University, College of Oriental Medicine, Kyunghee University)
  • 황화수 (경희대학교 동서의학대학원) ;
  • 남궁미애 (경희대학교 동서의학대학원) ;
  • 이은옥 (경희대학교 한의과대학) ;
  • 심범상 (경희대학교 한의과대학) ;
  • 안규석 (경희대학교 한의과대학) ;
  • 김성훈 (경희대학교 동서의학대학원, 경희대학교 한의과대학)
  • Published : 2007.12.25
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Abstract

According to the report of Korea National Statistical Office in 2007, cerebral vascular disease is second cause of deaths in Korean. Cerebral ischemia is one of the main reason of cerebral vascular diseases. To evaluate the neuroprotective effect of heyneanol A against cerebral ischemia, we used the middle cerebral artery occlusion model (MCAO). Heyneanol A from root of vitis amurensis Rup is a tetramer of resveratrol as known anti-oxidant and anti-cancer agent. Although the effects of resveratrol in the various fields have been well established, little is known of the effects of heyneanol A. In this study, heyneanol A reduced infarction and edema volume by 33.5% and 57% compared with control groups (vehicle), respectively. Also, neurological score was decreased by heyneanol A. It's effects were more potent than resveratol. Taken together, these results exerted that heyneanol A has a neuroprotective effect against cerebral ischemia.

Keywords

References

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