Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Inhibitory effects of Flowers of Lespedeza bicolor on Tyrosinase Activity and Melanin Synthesis

싸리꽃 추출물의 tyrosinase 활성 및 멜라닌합성 억제효과

  • Ryu, In-Sik (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Park, Si-Jun (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Mun, Yeun-Ja (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Ko, Joon-Suk (Department of Herhology & Precriptionology, College of Oriental Medicine, Sangji University) ;
  • Shin, Ki-Don (Department of Herhology & Precriptionology, College of Oriental Medicine, Sangji University) ;
  • Lee, Jang-Cheon (Department of Herhology & Precriptionology, College of Oriental Medicine, Sangji University) ;
  • Woo, Won-Hong (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lim, Kyu-Sang (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 유인식 (원광대학교 한의학전문대학원 제3의학과) ;
  • 박시준 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 문연자 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 고준석 (상지대학교 한의과대학 본초방제학교실) ;
  • 신기돈 (상지대학교 한의과대학 본초방제학교실) ;
  • 이장천 (상지대학교 한의과대학 본초방제학교실) ;
  • 우원홍 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 임규상 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2007.10.25
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Abstract

In this study, we investigated the effects of the flowers of Lespedeza bicolor on melanogenesis in a mouse melanocyte cell line, B16/F10 cells. Our results show that the flowers of Lespedeza bicolor significantly inhibits melanin synthesis in concentration-dependent manner. In addition, it was also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. While the flowers of Lespedeza bicolor have no direct inhibitory effect on tyrosinase activity in cell free assay system using mushroom tyrosinase. Moreover, the flowers of Lespedeza bicolor effectively suppressed the ${\alpha}-MSH-stimulated$ melanin formation, tyrosinase activity and dendrite outgrowth. These results suggest that the flowers of Lespedeza bicolor is a potent depigmetation agent.

Keywords

References

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