Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
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Chitosan and Its Derivatives for Gene Delivery

  • Published : 2007.04.30
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Abstract

Non-viral vectors, including lipid- or polymer-based systems, have attracted much attention to date as a gene delivery vehicle, due to safety issues with viral vectors. Chitosan, a naturally existing cationic polymer, has shown great potential as a gene delivery carrier, as it has low immunogenicity and toxicity, excellent transcellular transport ability, and is relatively easy to chemically modify. This review summarizes and discusses the general features of chitosan and its applications as a delivery carrier of DNA and RNA.

Keywords

References

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