Physical Therapy Korea (한국전문물리치료학회지)

Korean Research Society of Physical Therapy (한국전문물리치료학회)
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Effects of Improved Forelimb Sensorimotor Function on the Modified CIMT Applied Under the influence of Environmental Enrichment in a Focal Ischemic Brain Injury Rat Model

국소 허혈성 뇌손상 흰쥐 모델에서 환경강화 조건 하 수정된 건측억제유도 운동치료가 앞다리 운동기능 증진에 미치는 영향

  • Lee, Sam-Gyu (Dept. of Physical Medicine & Rehabilitation, Chonnam National University) ;
  • Kim, Gye-Yeop (College of Health & Welfare, Dongshin University) ;
  • Nam, Ki-Won (College of Health & Welfare, Dongshin University) ;
  • Oh, Myung-Hwa (College of Health & Welfare, Dongshin University) ;
  • Kim, Young-Eok (College of Health & Welfare, Dongshin University) ;
  • Kim, Eun-Jung (College of Health & Welfare, Dongshin University) ;
  • Jang, Mi-Kyoung (College of Health & Welfare, Dongshin University) ;
  • Kim, Kyung-Yoon (College of Health & Welfare, Dongshin University) ;
  • Jeong, Hyun-Woo (Dept. of Pathology, College of Oriental Medicine, Dongshin University) ;
  • Kim, Jong-Man (Dept. of Physical Therapy, Division of Health, Seonam University)
  • 이삼규 (전남대학교 의과대학 재활의학과) ;
  • 김계엽 (동신대학교 보건복지대학) ;
  • 남기원 (동신대학교 보건복지대학) ;
  • 오명화 (동신대학교 보건복지대학) ;
  • 김용억 (동신대학교 보건복지대학) ;
  • 김은정 (동신대학교 보건복지대학) ;
  • 장미경 (동신대학교 보건복지대학) ;
  • 김경윤 (동신대학교 보건복지대학) ;
  • 정현우 (동신대학교 한의과대학 병리학교실) ;
  • 김종만 (서남대학교 물리치료학과)
  • Received : 2007.05.28
  • Accepted : 2007.08.10
  • Published : 2007.09.17
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Abstract

Environmental Enrichment (EE) alone is not capable of enhancing the fine digit and the forelimb functions. Therefore, we applied modified constraint-induced movement therapy (mCIMT) under the influence of EE to assess its effect on promoting improved forelimb sensorimotor functions. Focal ischemic brain injury was produced in Sprague-Dawley rats (60 rats, $250{\pm}50$ g) through middle cerebral artery occlusion (MCAO). Before MCAO induction, all rats were trained in modified limb placing tests and reaching tasks for 1 week. Then they were randomly divided into three groups: Group I: application of standard environment (SE) after MCAO induction (n=20), Group II: application of EE after MCAO induction (n=20), Group III: MCAO+EE, mCIMT and task-oriented training that was initiated at 10th day after MCAO induction (n=20). We also applied mCIMT (between 9 AM and 5 PM/daily) which included restraining the forelimb ipsilateral to the lesion using the 'Jones & Schallert' method. We assessed the change of modified limb placing, single pellet reaching test and the immunoreactivity of BDNF by immunohistochemistry (pre, 1st, 5th, 10th and 20th day). Group I showed no improved outcome, whereas group II and III significantly improved on the use of the forelimb and the immunoreactivity. The qualitative analysis of the skilled reaching test, of group III showed the greatest improvement in the fine digit and the forelimb function. These results suggest that EE combined with mCIMT is more functional in promoting enhanced fine digit and forelimb functional movements.

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