Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
권호 표지
DOI QR코드

DOI QR Code

산삼과 산양삼 추출물의 항암 및 항산화 효능

  • Ahn, Young-Min (Dept. of Acup & Moxibustion, College of Oriental Medicine, Sangji University) ;
  • Park, Hee-Soo (Dept. of Acup & Moxibustion, College of Oriental Medicine, Sangji University) ;
  • Kwon, Ki-Rok (Dept. of Acup & Moxibustion, College of Oriental Medicine, Sangji University)
  • 안영민 (상지대학교 한의과대학 침구학교실) ;
  • 박희수 (상지대학교 한의과대학 침구학교실) ;
  • 권기록 (상지대학교 한의과대학 침구학교실)
  • Published : 2007.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The aim of this study was to verify anti-cancer and anti-oxidant efficacies of Korean wild ginseng and cultivated wild ginseng of Korea and China. Methods : For the measurement of anti-oxidation, SOD-like activity was evaluated using xanthine oxidase reduction method under in vitro environment. Subcutaneous and abdominal cancer were induced using CT-26 human colon cancer cells for the measurement of growth inhibition of cancer cells and differences in survival rate. Results : 1. Measurement of anti-oxidant activity of ginseng, Chinese and Korean cultivated wild ginseng, and natural wild ginseng samples showed concentration dependent anti-oxidant activity in HX/XOD system. Anti-oxidant activity showed drastic increase at 1mg/ml in all samples. 2. For the evaluation of growth inhibition of cancer cells after hypodermic implantation of CT-26 cancer cells in the peritoneal cavity of mice, Chinese and Korean cultivated wild ginseng and natural wild ginseng groups showed significant inhibition of tumor growth from the 12th day compared to the control group. Similar inhibitory effects were also shown on the 15th and 18th days. But there was no significant difference between the experiment groups. 3. For the observation of increase in survival rate of the natural wild ginseng group, CT-26 cancer cells were implanted in the peritoneal cavity of mice.

Keywords

References

  1. 신순식, 김경철, 최영현, 이용태, 엄현섭, 김창식. 산삼 감정 기준의 객관성. 한의학연구소 동의 한의연 제5집. 2001; 107-114
  2. 전국한의과대학 본초학교수 공편저. 본초학. 영림사. 1994; 531
  3. 약대사전 편찬위원회. 완역중약대사전. 정담. 1997; (7): 3473-3479
  4. 김성진, 신순식, 서부일, 지선영. 산삼, 장뇌삼, 인삼의 항암효과 비교연구. 대한본초학회지. 2004; 19(2); 41-50
  5. Se Na Yun, Sang Jung Moon, Sung Kwon Ko, Byung Ok Im, Sung Hyun Chung. Wild Ginseng Prevents the Onset of High-Fat Diet Induced Hyperglycemia and Obesity in ICR mice. Arch Pham Res. 2004; 27(7): 790-796 https://doi.org/10.1007/BF02980150
  6. Ki-Rok Kwon, Jung-Chul Seo. Genetical Identification of Korean Wild Ginseng and American Wild Ginseng by using Pyrosequencing Method. Kor. J. Herbology. 2004; 19(4): 45-50
  7. 권기록, 조아라, 이선구. 정맥주입용 산양산삼 증류약침의 급성, 아급성 독성 실험 및 Sarcoma-180 항암효과에 관한 실험적 연구. 대한약침학회지. 2003; 6(2): 7-27 https://doi.org/10.3831/KPI.2003.6.2.007
  8. 조희철, 이선구, 권기록. 농도별 산양산삼 증류약침의 apoptosis 에 관한 실험적 연구. 대한약침학회지. 2004; 7(2)1-15 https://doi.org/10.3831/KPI.2004.7.2.005
  9. 곡경승, 이선구, 권기록. pH 및 전해질 조절 산양산삼 증류약침의 apoptosis에 관한 실험적 연구. 대한침구학회지. 2004; 21(6): 1-17
  10. 권기록. 정맥주입용 산삼약침이 인체에 미치는 영향에 관한 임상적 연구. 대한약침학회지. 2004; 7(1): 15-26 https://doi.org/10.3831/KPI.2004.7.1.015
  11. Ki-Rok Kwon, Chi-Wan Park, Min-Soo Ra, Chong-Kwan Cho. Clinical Observation of Multiple Metastatic Cancer Patient with Hepatocellular Carcinoma treated with Cultivated Wild Ginseng Herbal Acupuncture Therapy, J. of Korean Acupuncture & Moxibustion Society, 2005; 22(2): 211-217
  12. 권기록, 윤휘철, 김호연. B16/F10 세포를 이식한 C57/BL6 생쥐에서 산삼약침의 항암효과 및 Doxorubicin에 의한 생식독성 완화효과. 대한침구학회지. 2006; 23(1): 105-120
  13. Devy, C. and Gautier, R. New perspectives on the biochemistry of superoxide anion and the efficiency of superoxide dismutase. Biochem. Pharmacol. 1990; 39: 399-405 https://doi.org/10.1016/0006-2952(90)90043-K
  14. Keum Y. S., Han S. S., Chun K. S., Park K. K., Park J. H., Lee S. K., Surh Y. J. Inhibitory effects of the gincenoside Rg3 od phorbol ester-induced cyclooxygenase-2 expression, NF-${\kappa}B$ activation and tumor promotion. Mutat Res. 2003; 75-85: 523-524
  15. 권기록, 위종성, 김성욱. 산삼에 대한 문헌적 고찰. 대한약침학회지. 2003; 6(2): 67-76 https://doi.org/10.3831/KPI.2003.6.2.067
  16. 單書健, 神農本草經校證, 吉林科學技術出版社. 1988; 150
  17. David R. Goldman. Complete Home Medical Guide. DK Publishing. 2003; 320
  18. http://www.nso.go.kr
  19. 潘敏求. 中華腫瘤治療大成. 河北科學技術出版社. 1996; 837-838
  20. 李家庚, 屈松柏 主編. 實用中醫腫瘤病學. 제2판. 北京. 科學技術文獻出版社. 2001; 694-697
  21. Woo, L.K., Nakamura, Y. and Donat, L. Effect of Korean Ginseng on the growth Rate of Cell. Arch. Ital. Patol. Clin. Tumori. 1965; 8: 53
  22. Shin, J.Y., Song, J.Y., Yun, Y.S., Yang, H.O., Rhee, D.K., Pyo, S. Immunostimulating effects of acidic polysaccharides extract of Panax ginseng on macrophage function. Immunopharmacol Immunotoxicol. 2002; 24: 469-482 https://doi.org/10.1081/IPH-120014730
  23. Song, J.Y., Han, S.K., Son, E.H., Pyo, S.N., Yun, Y.S., Yi, S.Y. Induction of secretory and tumoricidal activities in peritoneal macrophases by ginsan. Int Immunopharmacol. 2002; 2: 857-865 https://doi.org/10.1016/S1567-5769(01)00211-9
  24. Keum, Y.S., Han, S.S., Chun, K.S., Park, K.K., Park, J.H., Lee, S.K., Surh Y.J. Inhibitory effects of the ginsenosides Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-${\kappa}$B activation and tumor promotion. Mutat Res. 2003; 75-85: 523-224
  25. Yun, T.K. and Lee, Y.S. Comparison of anticarcino genecity between Panax ginseng C.A. Meyer and Panax quinquefolieds L. using Yun's nine-week medium term mouse model. Proceeding of the American Association for cancer research. 1999; 40
  26. Yun, T. K., Choi, S. Y. Cancer Epidemiol. Biomarkers Prevent. 1995; 4: 401
  27. 서성옥, 정철현, 손길수, The Ginseng Review. 1998; 25:10
  28. 곽이성, 김영숙, 신한재, 송용범, 박종대. 홍삼산성다당체(RGAP)와 항암제의 병행투여에 의한 항암시너지 효과. J. Ginseng Res. 2003; 27(2): 47-51 https://doi.org/10.5142/JGR.2003.27.2.047
  29. C.A. Rice, A. Diplock. Current of status of antioxident therapy. Free Radic. Biol. Med. 1993; 15: 77-96 https://doi.org/10.1016/0891-5849(93)90127-G

Cited by

  1. Mountain Ginseng Pharmacopuncture Treatment on Three Amyotrophic Lateral Sclerosis Patients vol.13, pp.4, 2010, https://doi.org/10.3831/KPI.2010.13.4.119