Environmental Analysis Health and Toxicology

환경독성보건학회 (The Korean Society of Environmental Health and Toxicology)
권호 표지

생물학적 모니터링 데이터를 기초한 PBPK 모델의 활용

Application of Physiologically Based Pharmacokinetic Modeling with Biological Monitoring Data for Risk Assessment

  • 양미희 (숙명여자대학교 약학대학 독성학교실) ;
  • 양지연 (숙명여자대학교 약학대학 독성학교실) ;
  • 이빛나 (숙명여자대학교 약학대학 독성학교실) ;
  • 이호선 (숙명여자대학교 약학대학 독성학교실)
  • Yang, Mi-Hi (Department of Toxicology, Sookmyung Women's University College of Pharmacy) ;
  • Yang, Ji-Yeon (Department of Toxicology, Sookmyung Women's University College of Pharmacy) ;
  • Yi, Bit-Na (Department of Toxicology, Sookmyung Women's University College of Pharmacy) ;
  • Lee, Ho-Sun (Department of Toxicology, Sookmyung Women's University College of Pharmacy)
  • 발행 : 2007.03.31
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초록

Biological monitoring, analyses of internal dose for exposure to toxicants, has been thought as one of the belt approaches for risk assessment. As the amount detected in human samples is generally very low, typically in the parts-per-bilion (ppb) or parts-per-trillion (ppt) range, analytic technologies such at HPLC, GC/MS, LC/MS, and LC/MS/MS have been continuously developed. In addition, route specific and sensitive exposure biomarkers have been developed for proper biological monitoring. PBPK modeling, particularly reverse dosimetry, has been emphasized as an useful method via interpretation of biological monitoring results for regulation of toxicants. Thus, this review is focused on the use of PBPK dosimetry models for toxicology research and risk assessment in Korea.

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참고문헌

  1. Backer LC, Ashley DL, Bonin MA, Cardinali FL, Kieszak SM and Wooten JV. Household exposures to drinking water disinfection by-products: whole blood trihalomethane levels, J Expo Anal Environ Epidemiol 2000; 10(4): 321-326 https://doi.org/10.1038/sj.jea.7500098
  2. Centers for Disease Control and Prevention (CDC). National Center for Health Stastics. National Health and Nutrition Examination Survey, 1988-94. Hyattsville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention. 1996
  3. Clewell HJ and Andersen ME. Risk assessment extrapolations andphysiological modeling, Toxicol Ind Health 1985; 1(4): 111-131 https://doi.org/10.1177/074823378500100408
  4. Corley RA, Gordon SM and Wallace LA. Physiologically based pharmacokinetic modeling of the temperaturedependent dermal absorption of chloroform by humans following bath water exposures, Toxicol Sci 2000; 53(1): 13-23 https://doi.org/10.1093/toxsci/53.1.13
  5. Jo WK, Weisel CP and Lioy PJ. Routes of chloroform exposure and body burden from showering with chlorinated tap water, Risk Anal 1990; 10(4): 575-580 https://doi.org/10.1111/j.1539-6924.1990.tb00541.x
  6. Levesque B, Ayotte P, Tardif R, Charest-Tardif G, Dewailly E, Prud'Homme D, Gingras G, Allaire S and Lavoie R. Evaluation of the health risk associated with exposure to chloroform in indoor swimming pools, J Toxicol Environ Health A 2000; 61(4): 225-243 https://doi.org/10.1080/00984100050136553
  7. Mayer PW, DeOreo WB, Opitz EM, Keifer JC, Davis WY, Dziegielewski B and Nelson JO. Residentail End Uses of Water. AWWA Research Foundation, Denver, CO. 2000
  8. Tan C, Liao K and Clewell H. Physiologically based pharmacokinetic modeling as a tool to interpret human biomonitoring data, CIIT ACTIVITIES 2005; 25(4): 1-8
  9. Tan YM, Liao KH, Conolly RB, Blount BC, Mason AM and Clewell HJ. Use of a physiologically based pharmacokinetic model to identify exposures consistent with human human biomonitoring datafor chloroform, J Toxicol Environ Health A 2006; 69(18): 1727-1756 https://doi.org/10.1080/15287390600631367
  10. U.S. EPA. Estimated per capita eater ingestion in the United States: based on Data collected by the United States Department of Agriculture's 1994-96 continuing survey of food intakes by individuals. Office of Water, Washington D.C. 2000
  11. U.S. EPA. Stage 1 distinfectants and disinfection byproducts rule: laboratory quick guide. 2002; Office of Water, Washington D.C
  12. U.S. EPA. Descriptive statistics tables from a detailed analysis of the National Human Activity Pattern Survey (NHAPS). Office of Research and Development, Las Vegas, NV. 1996
  13. Vlkel W, Colnot T, Csandy GA, Filser JG and Dekant W. Metabolism and Kinetics of Bisphenol A in Humans at Low Doses Following Oral Administration, Chem Res Toxicol 2002; 15(10): 1281-1287 https://doi.org/10.1021/tx025548t
  14. Wallace LA. Human exposure and body burden for chloroform and other trihalomethanes, Crit Rev Environ Sci Technol 1997; 27: 113-194 https://doi.org/10.1080/10643389709388513
  15. Weisel CP, Little JC, Chiu M, Pandis SN, Davidson C and Wilkes CR. Developing exposure estimates. In exposure to Contaminants in Drinking Water (S.S. Olin, Ed.). International Life Sciences Institute, Washington D.C. 1999
  16. Yang M, Koga M, Katoh T and Kawamoto T. A study for the proper application of urinary naphthols, new biomarkers for air-born polycyclic aromatic hydrocarbons, Arch Environ Contam Toxicol 1999; 36: 99-108 https://doi.org/10.1007/s002449900447
  17. Yang M and Pyo M. Molecular Epidemiology of Lung Cancer in Female Passive Smokers, J Environ Sci Health 2005; 23: 75-97 https://doi.org/10.1081/GNC-200052205