유한요소법에 의한 골강도와 micro-CT 지표 및 골밀도간의 상관관계

Analysis on correlation between bone strength by FEA, micro-CT parameters and bone mineral density

  • 윤영남 (원광대학교 치과대학 구강악안면 방사선학교실) ;
  • 이완 (원광대학교 치과대학 구강악안면 방사선학교실) ;
  • 이병도 (원광대학교 치과대학 구강악안면 방사선학교실)
  • Yoon, Young-Nam (Department of Oral & Maxillofacial Radiology, School of Dentistry, Wonkwang University) ;
  • Lee, Wan (Department of Oral & Maxillofacial Radiology, School of Dentistry, Wonkwang University) ;
  • Lee, Byung-Do (Department of Oral & Maxillofacial Radiology, School of Dentistry, Wonkwang University)
  • 발행 : 2007.03.31

초록

Purpose : Bone mineral density (BMD) and bone microarchitecture are important determinants for bone strength. Recently micro-CT have provided possibilities for measuring a variety of structural indices to characterize bone microarchitecture. The objective of this study was to compare the BMD and micro-CT parameters with Young's modulus calculated by finite element analysis (FEA) for the evaluation of bone strength. Materials and Methods Bone specimens were obtained from the 18 female rabbits aged 16 weeks. Of those, 36 samples (right and left femur) were selected for 3D micro-CT analysis $(ANT^{TM},\;SKYSCAN,\;Belgium)$ and BMD by PIXlmus 2 (GE Lunar Co. USA). Five microstructural parameters of micro-CT, such as trabecular thickness (Tb.Th), bone specific surface (BS/BV), percent bone volume (BV/TV), structure model index (SMI) and degree of anisotropy (DOA) were studied. Young's modulus was obtained by software program (ANSYS 9.0, ANSYS Inc, Canonsburg, PA) based on micro-CT three dimensional images. Results : Young's modulus assessed by FEA correlated significantly with Tb.Th, BV/TV, BS/BV and SMI respectively. Young's modulus showed higher correlation with these rnicrostructural parameters of micro-CT than BMD. Microstructural parameters except DOA showed significant correlations within the examined group. Conclusion The microarchitectural parameters o( micro-CT and BMD represented some informations in the evaluation of bone strength assessed by FEA.

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