Korean Journal of Biological Psychiatry (생물정신의학)
- Volume 14 Issue 1
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- Pages.42-47
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- 2007
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
Electroencephalographic Alpha Asymmetry in Major Depressive Disorder Patients With Anxiety Symptoms
불안을 동반한 주요우울장애 환자에 대한 뇌파 알파 비대칭의 특성 연구
- Lee, Jun-Seok (Department of Psychiatry, Kwandong University College of Medicine, Myongji Hospital) ;
- Yang, Byung-Hwan (Department of Neuropsychiatry, Hanyang University College of Medicine) ;
- Lee, So Hee (Department Psychiatry, National Medical Center) ;
- Lee, Seung-Min (Department Psychiatry, National Medical Center)
- 이준석 (관동대학교 의과대학 명지병원 정신과학교실) ;
- 양병환 (한양대학교 의과대학 신경정신과학교실 정신건강연구소) ;
- 이소희 (국립의료원 정신과) ;
- 이승민 (국립의료원 정신과)
- Published : 2007.02.28
Abstract
Objectives : Studies have reported differences between depressed adults and controls in quantitative measures of EEG alpha asymmetry, but, there are few using Korean subjects. So, the present study compared EEG regional alpha asymmetries of patients having major depressive disorder(MDD) and normal controls. Methods : The subjects in this study were 11 unmedicated unipolar depressed patients and 11 non-depressed, age matched controls. Resting EEG(eyes closed and eyes open) was recorded from each participant using 8 scalp electrodes. Beck Depression Inventory(BDI), 17-item Hamilton Depression Rating Scale(HDRS), Zung's Self-Rating Depression Scale(SDS) and Spielberger's State-Trait Anxiety Inventory(STAI) were used to evaluate depression and anxiety symptoms. Results : The severities of depression measured by self-report questionnaires were positively associated with those of anxiety(state and trait) ; The subjects were both anxious and depressed. Anxious-depressed patients differed from controls in alpha asymmetry at T4 channels. They showed evidence of greater activation over right than left temporal site. Conclusion : These findings are consistent with the previousely reported alpha asymmetry of depressed patients with an anxiety disorder. The failure to find the evidence of reduced right parietal activity in depression is presumed to be due to opposing effects of comorbid anxiety on parietotemporal activity.
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