A serological survey of Dirofilaria immitis infection in pet dogs of Busan, Korea, and effects of chemoprophylaxis

  • Byeon, Kang-Hyun (Department of Parasitology, Kosin University College of Medicine) ;
  • Kim, Bong-Jin (Department of Parasitology, Kosin University College of Medicine) ;
  • Kim, Sun-Mi (Department of Parasitology, Kosin University College of Medicine) ;
  • Yu, Hak-Sun (Department of Parasitology, Pusan National University College of Medicine) ;
  • Jeong, Hae-Jin (Department of Parasitology, Pusan National University College of Medicine) ;
  • Ock, Mee-Sun (Department of Parasitology, Kosin University College of Medicine)
  • 발행 : 2007.03.31

초록

The status of Dirofilaria immitis infection was assessed in pet dogs of Busan, Korea, and chemoprophylactic effects of microfilaricidal medication were evaluated. A total of 294 pet dogs older than 6 mo were examined, 217 of which had been maintained indoors, and 77 had been kept outdoors. The $Snap^R$ kit and direct microscopic examinations of the peripheral blood were used. The mean overall parasite positive rates were 10.2% and 6.5%, respectively. Outdoor dogs evidenced adult worm infection rate of 31.2% and microfilaria infection rate of 18.2%. The indoor dogs, however, evidenced adult worm infection rate of 2.8% and microfilaria infection rate of 2.3%. The prevalence in males was more than 2 times that of females. The changing pattern of infection rates by age evidenced a gradual increase, from 2- to 6-year-old dogs, after which, a decrease in infection rates was noted. With regard to chemoprophylaxis, the infection rates of complete and incomplete chemoprophylaxis groups were found to be 2-3 times lower than that of the non-chemoprophylaxis group. The results of the present study indicate that the risk of exposure to D. immitis in pet dogs is quite high, particularly in male outdoor dogs, and chemoprophylactic measures were quite effective.

키워드

참고문헌

  1. Ahid SM, Lourenco-de-Oliveira R, Saraiva LQ (1999) Canine heartworm on Sao Luis Island, Northeastern Brazil: a potential zoonosis. Cad Saude Publica 15: 405-412 https://doi.org/10.1590/S0102-311X1999000200025
  2. Capelli G, Poglayen G, Bertotti F, Giupponi S, Martini M (1996) The host-parasite relationship in canine heartworm infection in a hyperendemic area of Italy. Vet Res Commun 20: 320-330 https://doi.org/10.1007/BF00366538
  3. Clemence RG, Sarasola P, Genchi e. Smith DG, Shanks DJ, Jernigan AD, Rowan TG (2000) Efficacy of selamectin in the prevention of adult heartworm (Dirofilaria immitis) infection in dogs in northern Italy. Vet Parasitol 91: 251- 258 https://doi.org/10.1016/S0304-4017(00)00296-X
  4. Courtney CH and Zeng Q (2001) Comparison of heartworm antigen test kit performance in dogs having low heartworm burdens. Vet Parasito 96: 317-322 https://doi.org/10.1016/S0304-4017(01)00374-0
  5. Darrow JC, Lack EE (1981) Solitary lung nodule due to Dirofilaria immitis (dog 'heartworm'). J Surg Oncol16: 219-224 https://doi.org/10.1002/jso.2930160304
  6. Echeverri A, Long RF, Check W, Burnett CM (1999) Pulmonary dirofilariasis. Ann Thorac Surg 67: 201-202 https://doi.org/10.1016/S0003-4975(98)01060-1
  7. Foroulis CN, Khaldi L, Desimonas N., Kalafati G (2005) Pulmonary dirofilariasis mimicking lung tumor with chest wall and mediastinal invasion. Thorac Cardiovasc Surg 53: 173-175 https://doi.org/10.1055/s-2004-830567
  8. Glickman LT, Grieve RB, Breitschwerdt EB, Mika-Grieve M, Patronek GJ, Domanski LM, Root CR, Malone JB (1984) Serologic pattern of canine heartworm (Dirofilaria immitis) infection. Am J Vet Res 45: 1178-1183
  9. Graham JM (1974) Canine filariasis in northestern Kansas. J Parasitol 60: 322-326 https://doi.org/10.2307/3278475
  10. Grieve RB, Frank GR, Stewart VA, Parsons Je. Belasco DL, Hepler DI (1991) Chemoprophylactic effects of milbemycin oxime against larvae of Dirofilaria immitis during prepatent development. Am J Vet Res 52: 2040-2042
  11. Grieve RB, Lok JB, Glickman LT (1983) Epidermiology of canine heartworm infection. Epidemiol Rev 5: 220-246 https://doi.org/10.1093/oxfordjournals.epirev.a036260
  12. Kim MK, Kim CH, Yeom BW, Park SH, Choi SY, Choi JS (2002) The first human case of hepatic dirofilariasis. J Korean Med Sci 17: 686-690 https://doi.org/10.3346/jkms.2002.17.5.686
  13. Lee Je. Lee CY, Shin SS, Lee CG (1996) A survey of canine heartworm infections among German shepherds in South Korea. Korean J Parasitol 34: 225-231 https://doi.org/10.3347/kjp.1996.34.4.225
  14. Lee KJ, Park GM, Yong TS, Im K, Jung SH, Jeong NY, Lee WY, Young SJ, Shin KC (2000) The first Korean case of human pulmonary dirofilariasis. Yonsei Med J 41: 285- 288 https://doi.org/10.3349/ymj.2000.41.2.285
  15. Martherne CM, Green SP, Corwin RM, Kelley ST (1988) Detection of circulating Dirofilaria immitis antigens in random source laboratory dogs: evaluation of two commercial serodiagnostic tests. Lab Anim Sci 38: 584-587
  16. McCall JW, McTier TL, Ryan WG, Gross SJ, SolI MD (1996) Evaluation of ivermectin and milbemycin oxime efficacy against Dirofilaria immitis infections of three and four months' duration in dogs. Am J Vet Res 57: 1189-1192
  17. Song KH, Lee SE, Hayasaki M, Shiramizu K, Kim DH, Cho KW (2003) Seroprevalence of canine dirofilariosis in South Korea. Vet Parasitol114: 231-236 https://doi.org/10.1016/S0304-4017(03)00137-7
  18. Tagawa M, Okano S, Hayashi Y, Kusano K (1993) Prophylactic effect of milbemycin oxime against Dirofilaria immitis infection in dogs: optimum dose and administration time. J Vet Med Sci 55: 693-694 https://doi.org/10.1292/jvms.55.693