Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)
- Volume 17 Issue 1
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- Pages.43-50
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- 2007
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- 1225-6781(pISSN)
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- 2288-8802(eISSN)
Anti-Cancer and Anti-Allergy Activities of Mycelia Extracts of Lentinus edodes Mushroom-Cultured Glycyrrhiza radix
감초로 배양한 표고버섯 균사체 추출물이 항암 효과 및 알레르기 억제 효과 검증
- Bae, Man-Jong (Dept. of Herbal Foodceutical Science, Daegu Haany University) ;
- Yee, Sung-Tae (Dept. of Biology, Sunchon National University) ;
- Ye, Eun-Ju (Efficacy and Safety Research Center for Traditional Oriental Medicine, Daegu Haany University, Kyungbuk Technopark)
- Published : 2007.02.28
Abstract
This study investigated the effects of mycelia of Lentinus edodes mushroom-cultured Glycyrrihiza radix(LMG) on cancer cell lines and sarcoma 180(S-180), as well as on human mast cells. In an anti-cancer tests using Hep3B(hepatic cancer cell), MCF-7(breast cancer), and HeLa(uterine cancer) cells, LMG extract exhibited greater anti-proliferation effects than Glycyrrihiza glabra(GG) extract. LMG extract multiplication restraining effects were 60% that of ethanol at 3 mg/mL extract also displayed tumor suppressive effects in mice injected with S-180 cells. The growth-inhibition rates against tumor cells were 56% for LMG and 37% for GG. When LMG was added to human mast cells, the Intensity of RT-PCR products using primers(