Molecular & Cellular Toxicology

The Korean Society of Toxicogenomics and Toxicoproteomics (대한독성유전 단백체학회)
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The Anti-Inflammatory Effect of IH-901 in HT-29 Cells

  • Lee, Seung-Min (Department of Biochemistry & Molecular biology, Korea University Medical College) ;
  • Kim, Ki-Nam (Department of Biochemistry & Molecular biology, Korea University Medical College) ;
  • Kim, Yu-Ri (Department of Biochemistry & Molecular biology, Korea University Medical College) ;
  • Kim, Hye-Won (Department of Biochemistry & Molecular biology, Korea University Medical College) ;
  • Shim, Boo-Im (Department of Biochemistry & Molecular biology, Korea University Medical College) ;
  • Lee, Seung-Ho (Department of Biochemistry & Molecular biology, Korea University Medical College) ;
  • Bae, Hak-Soon (Department of Biochemistry & Molecular biology, Korea University Medical College) ;
  • Kim, In-Kyoung (Department of Biochemistry & Molecular biology, Korea University Medical College) ;
  • Kim, Meyoung-Kon (Department of Biochemistry & Molecular biology, Korea University Medical College)
  • Published : 2007.12.31
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Abstract

20-O-($\beta$-D-Glucopyranosyl)-20 (S)-protopanaxadiol (IH-901) is one of the major metabolites of ginsenosides from Panax ginseng, and is suggested that IH-901 has been associated with various pharmacological and physiological activities. In this study, we demonstrate that IH-901 induced anti-inflammation in HT-29 human colon adenocarcinoma cells. Our results showed that IH-901 inhibited cell proliferation of HT-29 in a time- and dose-dependent manner. We also found that IH-901 was significantly decreased expression of iNOS compared with non-treated. We observed effect of IH-901 related with inflammatory genes using by cDNA microarray. We were known that the 34 inflammatory genes such as E2F, CDK6, TNF-$\alpha$, and PKC were down-regulated. Thus, these results suggest that IH-901 may have a potential preventive factor to improving cancer induced by chronic inflammation.

Keywords

References

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