Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Changes in the Levels of Insulin-like Growth Factors (IGF-I and IGF-II) in Bovine Milk According to the Lactation Period and Parity

  • Kang, S.H. (Institute of Dairy Food Research, Seoul Dairy Cooperative) ;
  • Kim, J.U. (Division of Food Science, Korea University) ;
  • Kim, Y. (Division of Food Science, Korea University) ;
  • Han, K.S. (Division of Food Science, Korea University) ;
  • Lee, W.J. (Division of Animal Science and Technology, Gyeongsang National University) ;
  • Imm, J.Y. (Department of Food Science & Nutrition, Kookmin University) ;
  • Oh, S. (Department of Animal Science, Chonnam National University) ;
  • Park, D.J. (Korea Food Research Institute) ;
  • Moon, Y.I. (Department of Animal Health Management, Woosuk University) ;
  • Kim, S.H. (Division of Food Science, Korea University)
  • Received : 2006.02.16
  • Accepted : 2006.06.09
  • Published : 2007.01.01
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Abstract

The objectives of this study were to characterize the changes occurring in the levels of insulin-like growth factors (IGF-I and IGF-II) in bovine milk during a one-year lactation period, and to determine the parameters affecting IGF content in bovine milk. Milk was collected individually from lactating Holstein cows (n=70), and IGF-I and -II levels were determined via radioimmunoassay, using 125I after acid-ethanol treatment. The proximate compositions of the milk samples were determined using a near-infrared milk analyzer. The data were analyzed by the GLM and CORR procedures using SAS software to determine significant differences (p<0.05) occurring within groups (dairy farms, lactation periods, season, and parity). We noted an approximately six-fold reduction in the IGF-I concentration (from 2,462.7 to 353.0 ng/ml) and a three-fold drop in the IGF-II concentration (from 929.1 to 365.7 ng/ml) in the bovine colostrum, between 6 h after parturition and 18 h after parturition. IGF-I and -II content, measured at the early, middle, and late stages of lactation did not change significantly throughout the entirety of the lactation period. Interestingly, parity did not significantly affect IGF-I content, but did significantly affect IGF-II content between the primiparous and multiparous cows. We also found there were no significant relationships between IGF-I and total protein content or somatic cell counts (p<0.05).

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References

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