Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
권호 표지

TTF-1 Expression in PACAP-expressing Retinal Ganglion Cells

  • Son, Young June (Department of Biological Sciences, College of Natural Sciences, University of Ulsan) ;
  • Park, Jeong Woo (Department of Biological Sciences, College of Natural Sciences, University of Ulsan) ;
  • Lee, Byung Ju (Department of Biological Sciences, College of Natural Sciences, University of Ulsan)
  • Received : 2006.12.07
  • Accepted : 2007.01.10
  • Published : 2007.04.30
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Abstract

In mammals light input resets the central clock of the suprachiasmatic nucleus by inducing secretion of pituitary adenylate cyclase-activating polypeptide (PACAP) from retinal ganglion cells (RGCs). We previously showed that thyroid transcription factor 1 (TTF-1), a homeodomain-containing transcription factor, specifically regulates PACAP gene expression in the rat hypothalamus. In the present study we examined the expression of TTF-1 in PACAP-synthesizing retinal cells. Fluorescence in situ hybridization (FISH) showed that it is abundantly expressed in RGCs of the superior region of the retina, but in only a small subset of RGCs in the inferior region. Double FISH experiments revealed that TTF-1 is exclusively expressed in PACAP-producing RGCs. These results suggest that TTF-1 plays a regulatory role in PACAP-expressing retinal ganglion cells.

Keywords

Acknowledgement

Supported by : Korea Science and Engineering Foundation (KOSEF)

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