Korean Chemical Engineering Research

The Korean Institute of Chemical Engineers (한국화학공학회)
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Synthesis of Ag-Hydroxyapatite Antibiotic Material by Coprecipitation Method

공침법을 이용한 은-수산화아파타이트 항균소재의 제조

  • Jang, Kwang-Kyu (Department of Chemical Engineering, Seoul National University of Technology) ;
  • Shin, Hun Yong (Department of Chemical Engineering, Seoul National University of Technology)
  • 장광규 (서울산업대학교 화학공학과) ;
  • 신헌용 (서울산업대학교 화학공학과)
  • Received : 2006.12.22
  • Accepted : 2007.05.22
  • Published : 2007.10.31
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Abstract

Antibiotic composite was synthesized by coprecipitation of silver nitrate into hydroxyapatite. Adsorbed amount of silver ion was examined by the variation of concentration of silver nitrate, temperature, pressure and curing time. Optimum condition for silver-hydroxyapatite adsorption could be achieved. Physical and chemical characteristic properties of synthesized silver-hydroxyapatite were tested by ICP-MS, SEM-EDAX, DSC and XRD. Antibiotic properties for gram positive staphylococcus aureus (ATCC 6538) and gram negative escherichia coli (ATCC 25922) were tested by shake flake method.

공침법을 이용하여 질산은($AgNO_3$)을 수산화아파타이트(hydroxyapatite)에 흡착시켜 복합항균제를 제조하였다. 질산은의 농도, 온도, 압력, 숙성시간에 따른 흡착된 은이온양의 변화를 관찰하였고, 은-수산화아파타이트 흡착의 최적조건을 얻었다. 제조된 은-수산화아파타이트를 ICP-MS, SEM-EDAX, DSC, XRD를 이용하여 물리적 화학적 특성을 고찰하였다. 또한 제조된 은-수산화아파타이트는 진탕플라스크실험법(shake flask method, KS M-146-2003)을 이용하여 양성균인 황색포도상구균(staphylococcus aureus, ATCC 6538)과 음성균인 대장균(escherichia coli, ATCC 25922)의 항균성을 확인하였다.

Keywords

Acknowledgement

Supported by : 중소기업청

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