A Study on the Subchronic Inhalation Toxicity of 2-Butanethiol Using SD Rats

2-부탄티올의 SD Rats를 이용한 아만성 흡입독성연구

  • Kim, Hyeon-Yeong (Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agency) ;
  • Lee, Sung-Bae (Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agency) ;
  • Lim, Cheol-Hong (Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agency) ;
  • Cho, Hae-Won (Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agency) ;
  • Kang, Min-Gu (Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agency) ;
  • Lee, Jun-Yeon (Korea Testing & Research Institute)
  • 김현영 (한국산업안전공단 산업안전보건연구원) ;
  • 이성배 (한국산업안전공단 산업안전보건연구원) ;
  • 임철홍 (한국산업안전공단 산업안전보건연구원) ;
  • 조해원 (한국산업안전공단 산업안전보건연구원) ;
  • 강민구 (한국산업안전공단 산업안전보건연구원) ;
  • 이준연 (한국화학시험연구원)
  • Received : 2007.05.22
  • Accepted : 2007.07.05
  • Published : 2007.09.30

Abstract

With the 2-Butanethiol, which is an unidentified inhalation toxic material, acute inhalation toxicity was tested with SD rats. The $LC_{50}$ was evaluated to be 2,500 ppm (9.22 mg/L) or higher which falls under the criteria of acute toxicity Category 3 (500<$LC_{50}$<2,500 ppm) in the Industrial Safety and Health Act. In the subchronical inhalation toxicity test by 0, 25, 100, and 400 ppm, 6 hours a day, 5 days a week, for 13 weeks repeated exposure, though no death or particular clinical presentation was observed, in the female 25 and 400 ppm group, including weight change, and in each concentration group including 400 ppm, change of feed rate, eye stimulation, motility change in male group, and lesions in blood and blood biochemical were observed. In the internal organs weight, 25, 100, and 400 ppm groups in male and 400 ppm group in female showed significant (p<0.05) changes in kidney, liver, thymus, and lung. In the pathological tissue test, severe cortical tubular hyaline droplets were observed in the male 400 ppm group, and all male rats of 400 ppm group and 2 female individuals showed tubular degeneration/regeneration accompanied with pigmentation, showing that the target organs of inhalation exposure of 2-Butanethiol are spleen, kidney, nasal cavity, and adrenal. Through the tests, the NOEL of 2-Butanethiol was evaluated to be 25 ppm (0.092 mg/L) or less for both male and female.

Keywords

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