Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
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Multiple Symmetric Lipomatosis: Characteristics and Treatment in Korean Patients

다발성 대칭성 지방종증: 한국인에서의 특징 및 치료

  • Cheon, Young Woo (Institute for Human Tissue Restoration & Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, Korea) ;
  • Roh, Tae Suk (Institute for Human Tissue Restoration & Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine) ;
  • Kim, Yong Oock (Institute for Human Tissue Restoration & Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine) ;
  • Kwon, Ji Eun (Department of Pathology, Yonsei University College of Medicine) ;
  • Tark, Kwan Chul (Institute for Human Tissue Restoration & Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine) ;
  • Yoo, Won Min (Institute for Human Tissue Restoration & Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine)
  • 전영우 (연세대학교 의과대학 성형외과학교실. 인체조직복원연구소) ;
  • 노태석 (연세대학교 의과대학 성형외과학교실. 인체조직복원연구소) ;
  • 김용욱 (연세대학교 의과대학 성형외과학교실. 인체조직복원연구소) ;
  • 권지은 (연세대학교 의과대학 병리학교실) ;
  • 탁관철 (연세대학교 의과대학 성형외과학교실. 인체조직복원연구소) ;
  • 유원민 (연세대학교 의과대학 성형외과학교실. 인체조직복원연구소)
  • Received : 2007.04.09
  • Published : 2007.07.10
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Abstract

Purpose: Multiple symmetric lipomatosis (MSL) is a relatively rare disorder characterized by presence of multiple, symmetric, nonencapsulated fat masses in face, neck, shoulder and other areas. There has been only a few cases reported in Korea. The main purpose of this research is to examine the Korean patients to see what kinds of special characteristics occurred due to this disease and to decide the proper treatment.Methods: A total of 16 patients were evaluated retrospectively. 5 patients were treated at our hospital. The other patients were reviewed from literature. We analyzed the biological characters of patients, location of fat deposit, morphologic characters of patients, clinical evidence of neuropathy, associated metabolic disorders and treatment modality.Results: All cases were male patient. The mean age of onset was 47.43 years. All patients were moderate to heavy alcoholics. The most common location of fat deposition was posterior neck and abdomen. In neurologic exam of 9 patients, 5 patients showed muscle weakness, tremor, pain and autonomic nerve dysfunction. In metabolic studies of 9 patients, total cholesterol values were higher in 1 patient. A glucose tolerance test was abnormal in 1 patient. In treatment modality, 14 patients were treated with surgical resection, 1 patient was treated with liposuction and surgical excision, 1 patient was treated only with liposuction. Conclusion: To treat MSL patients successfully, we should concentrate not only on the removal of the fatty tissue but also on neurologic abnormities, metabolic disorders and associated diseases.

Keywords

References

  1. Enzi G: Multiple symmetric lipomatosis: an updated clinical report. Medicine(Batimore) 63: 56, 1984 https://doi.org/10.1097/00005792-198401000-00004
  2. Nisoli E, Regianini L, Briscini L, Bulbarelli A, Busetto L, Coin A, Enzi G, Carruba MO: Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cells. J Pathol 198: 378, 2002 https://doi.org/10.1002/path.1212
  3. Enzi G, Angelini C, Negrin P, Armani M, Pierobon S, Fedele D: Sensory, motor and autonomic neuropathy in patients with multiple symmetrical lipomatosis. Medicine (Baltimore) 64: 388, 1986
  4. Huh C, Lim SO, Mun GH, Hyon WS, Bang SI, Oh GS: Treatment of benign multiple symmetrical lipomatosis with liposuction. J Korean Soc Plast Reconstr Surg 33: 769, 2006
  5. Kim SW, Seo DW, Lee SJ, Chung YK: Benign symmetrical lipomatosis. J Korean Soc Plast Reconstr Surg 29: 527, 2002
  6. Rhee JH, Hong JM, Ahn JH: Multiple symmetric lipomatosis. Korean J Thorac Cardiavasc Surg 29: 244, 1996
  7. Sung RH, Yang WS: Multiple symmetric lipomatosis. Korean J Pathol 22: 484, 1988
  8. Park ES, Lee WS, Song JY: A case of benign symmetric lipomatosis. Korean J Dermatol 27: 603, 1989
  9. Sung YO, Lee JH, Kim KH, Suh MK, Park JK: Three cases of benign symmetric lipomatosis. Korean J Dermatol 31: 800, 1993
  10. Park SK, Houh D, Kim HO, Kim CW: Two cases of benign symmetrical lipomatosis. Korean J Dermatol 27: 752, 1989
  11. Kang SJ, Chang M: Benign symmetric lipomatosis. J Korean Soc Plast Reconstr Surg 27: 117, 1984
  12. Ujpal M, Nemeth ZS, Reichwein A, Szabo GY: Long-term results following surgical treatment of benign symmetric lipomatosis(BSL). Int J Oral Maxillofac Surg 30: 479, 2001 https://doi.org/10.1054/ijom.2001.0162
  13. Busetto L, Strater D, Enzi G, Coin A, Sergi G, Inelmen EM, Pigozzo S: Differential clinical expression of multiple symmetric lipomatosis in men and women. Int J Obes Relat Metab Disord 27: 1419, 2003 https://doi.org/10.1038/sj.ijo.0802427
  14. Martinez-Escribano JA, Gonzalez R, Quecedo E, Febrer I: Efficacy of lipectomy and liposuction in the treatment of multiple symmetric lipomatosis. Int J Dermatol 38: 551, 1999 https://doi.org/10.1046/j.1365-4362.1999.00743.x
  15. Gonzalez-Garcia R, Rodriguez-Campo FJ, Sastre-Perez J, Munoz-Guerra MF: Benign symmetric lipomatosis (Madelung's disease): case reports and current management. Aesthetic Plast Surg 28: 108, 2004