Journal of Dental Rehabilitation and Applied Science (구강회복응용과학지)

Korean Academy of Stomatognathic Function and Occlusion (대한턱관절교합학회)
권호 표지

Effects of Botulinum Toxin Type A Injection into Masseter Muscle on the Jaw Growth in Rats

교근부 보툴리눔 A형 독소(Botulinum Toxin Type A) 주사가 쥐의 턱뼈 성장에 미치는 영향

  • Yoon, Seung-Hyun (Department of Oral Medicine, College of Dentistry, Yonsei University) ;
  • Kim, Ji-Yeon (Department of Pediatric Dentistry, School of Medicine, Sungkyunkwan University) ;
  • Kim, Seong-Taek (Department of Oral Medicine, College of Dentistry, Yonsei University)
  • 윤승현 (연세대학교 치과대학 구강내과학교실) ;
  • 김지연 (성균관대학교 의과대학 삼성서울병원 소아치과) ;
  • 김성택 (연세대학교 치과대학 구강내과학교실)
  • Published : 2007.06.30
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Abstract

Botulinum toxin type A (BTX-A) has a local effect at the neuromuscular junction by blocking acetylcholine release and thus causing paralysis and atrophy of the affected muscles. In dentistry, Botulinum toxin type A(BTX-A) is used for the treatment of masseteric hypertrophy, temporomandibular disorder, and severe bruxism related neurologic disorder. We hypothesized that the muscle atrophy after BTX-A injection into masseter muscle in growing rats, could affect the jaw growth. The purpose of this study was to determine the effects of the BTX-A injected into the masseter muscle on the jaw growth in rats. Rats were divided into four groups(group 1; control group, group 2; saline injection group, group 3; BTX-A injection group, group 4; baseline control group). Group 4 was sacrificed at the beginning of the experiment to provide baseline values of jaw measurements. The weight, length and width of jaw in those groups were measured every weeks. This study reported that the mandibular body length, condylar length, coronoid process length, anterior region height, coronoid process height and condylar height of the jaw in BTX-A injection group were shorter than those of the control and saline injection groups(P<0.05). In conclusion, BTX-A injected into the masseter muscle may affect the undergrowth of the jaw in rats.

Keywords

References

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