Mycobiology

The Korean Society of Mycology (한국균학회)
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The Neuroprotective and Neurotrophic Effects of Tremella fuciformis in PC12h Cells

  • Park, Kum-Ju (Institute of Food & Culture R&D Center, Pulmuone Co., Ltd.) ;
  • Lee, Sang-Yun (Institute of Food & Culture R&D Center, Pulmuone Co., Ltd.) ;
  • Kim, Hyun-Su (Division of Life Sciences, Kyungnam University) ;
  • Yamazaki, Matsumi (Department of Biodynamics, Faculty of Pharmaceutical Sciences, Hokuriku University) ;
  • Chiba, Kenzo (Department of Biodynamics, Faculty of Pharmaceutical Sciences, Hokuriku University) ;
  • Ha, Hyo-Cheol (Institute of Food & Culture R&D Center, Pulmuone Co., Ltd.)
  • Published : 2007.03.31
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Abstract

We examined the neuroprotective and neurotrophic effects of Tremella fuciformis. The neurotrophic effects of the hot water extract of T. fuciformis was evaluated by microscopically monitoring its potency to induce neurite outgrowth in PC12h cells. The hot water extract cf T. fuciformis promoted neurite outgrowth in PC12h cells in this study, superior to other natural substances which was reported previously. When cells were treated with the hot water extract of T. fuciformis prior to ${\beta}$-amyloid peptide treatment (active domain of A peptide $35{\sim}35$ treated), toxicity was significantly diminished (p<0.01). These results suggest that T. fuciformis might potentially be used as a precautionary agent in neurodegenerative disease, such as Alzheimer's disease, etc.

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References

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