Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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EPITHELIAL-MYOEPITHELIAL CARCINOMA ARISING IN PLEOMORPHIC ADENOMA OF PALATE

다형성 선종에서 발생한 구개부의 상피성-근상피암종

  • Kim, Kyung-Wook (Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University) ;
  • Han, Se-Jin (Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University)
  • 김경욱 (단국대학교 치과대학 구강악안면외과학교실) ;
  • 한세진 (단국대학교 치과대학 구강악안면외과학교실)
  • Published : 2007.10.31
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Abstract

A case of epithelial-myoepithelial carcinoma transformed in pleomorphic adenoma occurring in palate of a 61 years old woman is reported. The tum or was composed of 2 different components, pleomorphic adenoma and epithelial myoepithelial carcinoma, accounting for approximately 40% and 60% of whole tumor, respectively. As the results of the immunohistopathologic study, epithelial-myoepithelial carcinoma showed multiple tubular or solid nest, which were separated by a basement membrane and considered of variable proportion of 2 cell types, cuboidal epithelial cells positive for cytokeratin and clear myoepithelial cells positive for glial fibrillary acid protein, wheres the myoepithelial nest of pleomorphic adenoma intermingled with hyaline and myxoid stroma. The malignancy was demonstrated by convincing evidence of invasion into the submucosa, although the epithelial-myoepithelial carcinoma component was mostly surrounded by the pleomorphic adenoma componemts. An increased immunoreactivity of proliferating cell nuclear antign in the epithelial myoepithelial carcinoma area in comparison to the pleomorphic adenoma also suggested epithelial-myoepithelial carcinoma arising in a pleomorphic adenoma.

본 교실에서는 상악 구개부의 무통성 종창을 주소로 내원한 다형성 선종의 병력을 가진 환자에 대한 임상적, 조직병리학적, 면역병리학적 검사들을 통하여 최종적으로, 드물게 발병하는 다형성 선종 유래 악성 상피성-근상피암종으로 진단하였으며, 상악골 부분 절제술 및 측두근 피판 지연 재건술 시행 후 현재까지 재발의 소견 없이 양호한 치료 결과를 얻었기에 보고하는 바이다.

Keywords

References

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