Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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EFFECTS OF VARIOUS NSAIDS ON PROSTAGLANDIN SYNTHESIS AND CELLULAR CONFIGURATION OF HUMAN PERIODONTAL LIGAMENT CELLS

다양한 NSAID가 인간 치주인대세포의 prostaglandin 합성 및 세포 형태에 미치는 효과에 대한 연구

  • Kim, Hyeok-Soo (Dept. of Orthodontics, College of Dentistry, Seoul National University) ;
  • Shim, Hae-Young (Dept. of Dentistry, Boramae Hospital) ;
  • Chae, Chang-Hoon (Institute of Nano-Bio Fusion Technology, NanoCureTech Inc) ;
  • Chang, Young-Il (Dept. of Orthodontics, College of Dentistry, Seoul National University) ;
  • Park, Jun-Woo (Dept. of Dentistry, College of Medicine, Hallym University)
  • 김혁수 (서울대학교 치과대학 교정학교실) ;
  • 심혜영 (서울특별시립 보라매병원 치과) ;
  • 채창훈 (나노큐어텍 나노-바이오 퓨전 부설연구소) ;
  • 장영일 (서울대학교 치과대학 교정학교실) ;
  • 박준우 (한림대학교 의과대학 치과학교실)
  • Published : 2007.10.31
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Abstract

The present study was designed to evaluate effects of the commonly used NSAIDs(acetaminophen, aspirin, and ibuprofen) on human periodontal ligament cells. Human periodontal ligament cells were grown from a cell line provided by Kyungpook National University. Effects of NSAIDs on the proliferation of human periodontal ligament cells were assessed using MTT assays. And then $PGE_2$ concentrations were determined by ELISA and the changes of cellular configuration were found by electron micrograph. The results were as follows; 1. The MTT assay demonstrated that the commonly used NSAIDs(acetaminophen, aspirin, and ibuprofen) had not significant cytotoxic effect on human periodontal ligament cells. 2. NSAIDs inhibited the $PGE_2$ synthesis of human periodontal ligament cells compared with the control group. These inhibitory effects had no significant differences with NSAID type and concentration. 3. Electron micrographs of human periodontal ligament cells treated with NSAIDs showed more narrow and irregular shape.

Keywords

References

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