References
- Hromas RA, North JA, Burns CP: Decreased cisplatin uptake by resistant L1210 leukemia cells. Cancer Lett 1987;36(2):197-201 https://doi.org/10.1016/0304-3835(87)90091-7
- Vikran B, Strong E, Shah J et al.: Failure at the primary site-following multimodality treatment for advanced head and neck cancer. Head Neck Surg 1984;6:720
- Lockshin RA and Williams CM: Programmed cell death. II. Endocrine potentiation of the breakdown of the intersegmental muscles of silkmoths. J Insect Physiol 1964;10:643-649 https://doi.org/10.1016/0022-1910(64)90034-4
- Choi EJ: Experimental & Molecular medicine Vol.33 Supplement, December 2001;83-93 https://doi.org/10.1038/emm.2001.15
- Fadeel B, Gleiss B, Hogstrand K et al: Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression. Biochem Biophys Res Commun 1996;266(2):504-11
- Kaufmann SH, Earnshaw WC: Induction of apoptosis by cancer chemotherapy. Exp Cell Res 2000;256(1):42-9 https://doi.org/10.1006/excr.2000.4838
- Amos LA, Lowe J: Chem. Biol. 6, 65-69, 1999 https://doi.org/10.1016/S1074-5521(99)89002-4
- Crown J, O'Leary M: Lancet 355,1176-1178, 2000 https://doi.org/10.1016/S0140-6736(00)02074-2
- Haldar S, Jena N, Croce CM: Inactivation of Bcl-2 by phosphorylation. Proc Natl Acad Sci USA 1995;9:92(10):4507-4511
- Wang TH, Popp DM, Wang HS, et al.: Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal Kinase(JNK)-dependent and independent pathways in ovarian cancer cell. J Biol Chem 1999;19(274)12:8208-8216
- Lu KH, Leu K, Liao HH, et al.: Induction of caspase -3-dependent apoptosis in human leukemia HL-60 cells by paclitaxel. Clin Chem Acta 2005;357(1):65-73 https://doi.org/10.1016/j.cccn.2005.02.003
- Park SJ, Wu CW, John D, et al. : Taxol Induces Caspase-10-dependent Apoptosis. J Bio Chem 2004;279(49) :51057-51067 https://doi.org/10.1074/jbc.M406543200
- Jordan MA, Wendell K, Gardiner S, et al.: Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 1996;56(4):816-825
- Yvon AM, Wadsworth P, Jordan MA: Taxol suppresses dynamics of individual microtubules in living human tumor cells. Mol Biol Cell 1999;10(4):947?959
- Laupacis A, Keown PA, Ulan RA: Cyclosporin A : a powerful immunosuppessant. Can med Assoc J 1986;126:1041
- Satoshi M, Shigeo K: Mechanisms of action of cyclosporine. Immunopharm 2000;47:119-125 https://doi.org/10.1016/S0162-3109(00)00192-2
- Braida M, Knop J: Effect of cyclosporin A on the T-effector and Tsuppressor cell response in contact sensitivity. Immun 1986;59:503-511
- Mongini C, Waldner C, Lopes EC, et al.: Induction of apoptosis in murine lymphoma cells by cyclosporin A. Int J Mol Med 2001; 7(4):431-437
- Healy E, Dempsey M, Lally C, et al.: Apoptosis and necrosis : mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line. Kidney Int 1998;54(6):1955-1966 https://doi.org/10.1046/j.1523-1755.1998.00202.x
- Justo P, Lorz C, Sanz A, et al.: Intracellular mechanisms cyclosporin A-induced tubular cell apoptosis. J Am Soc Nephrol 2003; 14(12):3072-3080 https://doi.org/10.1097/01.ASN.0000099383.57934.0E
- Zupanska A, Dziembowska M, Ellert MA, et al.: Cyclosporine A induces growth arrest or programmed cell death of human glioma cells. Neuro chem Int 2005;47(6):430-441 https://doi.org/10.1016/j.neuint.2005.05.010
- Lim HW, Kim KW: Anti-cancer effect of Cyclosporin A on oral squamous cell carcinoma cell line J Kor Oral Maxillofac Surg 2004;30(06):474-481
- Meerum-Terwogt JM, Malingre MM, Beijnen JH, et al.: Coadministration of oral cyclosporin A enables oral therapy with paclitaxel. Cli. Cancer Res 1999;5:3379-3384
- Kimura Y, Aoki J, Kohno M, et al.: P-glycoprotein inhibition by the multidrug resistance-reversing agent MS-209 enhances bioavailability and antitumor efficacy of orally administered paclitaxel. Cancer Chemother Pharmacol 2002;49(4):322-8 https://doi.org/10.1007/s00280-001-0419-x
- Mirte MM, Dick JR, Jos H, et al.: Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel. J Clin Oncology 2001;19(4):1160-1166 https://doi.org/10.1200/JCO.2001.19.4.1160
- Koshkina NV, Golunski E, Roberts LE, et al.: Cyclosporin A aerosol improves the anticancer effect of paclitaxel aerosol in mice. J Aerosol Med 2004;17(1):7-14 https://doi.org/10.1089/089426804322994415
- Meerum Terwogt JM, Malingre MM, Beijnen JH, et al.: Clin Cancer Res. 1999;5(11):3379-84
- Lin HL, Lui WY, Liu TY, Chi CW: Reversal of Taxol resistance in hepatoma by cyclosporin A : involvement of the Pl-3 Kinase-Akt 1 pathway .British Jounal of Cancer 2003;88,973-980 https://doi.org/10.1038/sj.bjc.6600788
- Andjelkovic M, Jakubowicz T, Cron P, et al.: Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci USA 1996;93(12):5699-5704
- Datta SR, Dudek H, Tao X, et al.: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91(2):231-241 https://doi.org/10.1016/S0092-8674(00)80405-5
- Watanabe H, Saito H, Rychahou PG, et al.: Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinosito 3-kinase/Akt activation. Gastroenterology. 2005;128(5):1391-1404 https://doi.org/10.1053/j.gastro.2005.03.016
- Jin Q. Cheng: Phosphoinositide 3-Kinase/Akt1 Pathway and Human Ovarian Cancer SEP 2002. Annual rept. 1 Sep 2001-31 ug 2002
- Neri LM, Borgatti P, Tazzari PL, Bortul R, Cappellini A, Tabellini G, Bellacosa A, Capitani S, Martelli AM: The phosphoinositide 3-kinase/Akt1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells. Mol Cancer Res 2003;1(3):234-46
- Polakis P: The adenomatous polyposis coli (APC) tumor suppressor. Biochim Biophys Acta 1997;1332(3):F127-F147
- Brown JD, Moon RT. Wnt signaling: Why is everything so negative? Curr Opin Cell Biol 1998;10(2):182-187 https://doi.org/10.1016/S0955-0674(98)80140-3
- Bafico A, Liu G, Yaniv A, et al.: Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol 2001;3(7):683-686 https://doi.org/10.1038/35083081
- Ohigashi T, Mizuno R, Nakashima J, et al.: Inhibition of Wnt Signaling Downregulates Akt Activity and Induces Chemosensitivity in PTEN-Mutated Prostate CancerCells Prostate 2005;62:61-68 https://doi.org/10.1002/pros.20117
- Simpson L, and Parsons R: PTEN : life as a tumor suppressor. Exp. Cell Res 2001;264:29-41 https://doi.org/10.1006/excr.2000.5130
- Maitra A, Hruban RH: A new mouse model of pancreatic cancer: PTEN gets its Akt together. Cancer Cell 2005;8(3):171-2 https://doi.org/10.1016/j.ccr.2005.08.007
- Arnaud B, Stephen MR, V. Wee Yong: PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis. Eur J Biochem 1999;263:605-611 https://doi.org/10.1046/j.1432-1327.1999.00542.x
- Tamai K, Semenov M, Kato Y, et al: LDL-receptor-related proteins in Wnt signal transduction. Nature 2000;407(6803):530-535 https://doi.org/10.1038/35035117
- Li H, Zhu H, Xu C, et al: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998;94(4):491-501 https://doi.org/10.1016/S0092-8674(00)81590-1
- Amundson SA, Myers TG, Scudiero D, et al: An informatics approach identifying markers of chemosensitivity in human cancer cell lines Res 2000;60:6101-6110
- Reed JC: Prosmise and problem of Bcl-2 antisene therapy. J Natl / Cancer Inst 1997;89, 988-990 https://doi.org/10.1093/jnci/89.14.988
- Haldar S, Basu A, Croce CM: Bcl-2 is the guardian of microtubule integrity. Cancer Res 1997;57:229-233
- Stahl U, Wenk J, Wagener F, et al: Phosphoinositide 3-kinase(PI3-K) expression. Tumorigenesis of epithelial carcinoma of the mouth. Pathologe 2004;25(1):31-7 https://doi.org/10.1007/s00292-003-0673-2
- Paez GP, Sellers WR: The PI3K/PTEN/Akt pathway: A critical mediator of oncogenicsignaling. In: Frank DA, ed. Signal Transduction in Cancer. Cancer Treat Res 2003;115:145-67
- Fruman, Meyers & Cantley, Katso et al., 2001; Vanhaesebroeck & Waterfield, 1999
- Vazquez F, Sellers WR: The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signalling. Biochem Biophys Acta 2000;1470:M21-M35
- Kandel ES, Hay N: The regulation and activities of the multi-functional serine/threonine kinase Akt/PKB. Exp Cell Res 1999;253:210-229 https://doi.org/10.1006/excr.1999.4690
- Stein RC, Waterfield MD: PI3-kinase inhibition : a target for drug development? Mol Med Today 2000;6:347-357 https://doi.org/10.1016/S1357-4310(00)01770-6
- Vanhaesebroeck B, Waterfield MD: Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res. 253:239-254. doi:10.1006/excr. 4701, 1999
- Datta SR, Brunet A, Greenberg ME: Cellular survival : a play in three Akts. Genes Dev 1999;13(22):2905-27 https://doi.org/10.1101/gad.13.22.2905
- Plas DR, Thompson CB: Akt-dependent transformation : there is more to growth than just surviving. Oncogene 2005;24(50):7435-7442 https://doi.org/10.1038/sj.onc.1209097
- Zimmermann S, Moelling K: Phosphorylation and regulation of Raf by Akt(protein kinase B). Science 1999;286(5445):1741-1744 https://doi.org/10.1126/science.286.5445.1741
- Daniel T. Bergstralh, Jenny PY. Ting: Microtubule stabilizing agents: Their molecular signaling consequences and the potential for enhancement by drug combination Cancer Treatment Reviews 2000;32:166-179 https://doi.org/10.1016/j.ctrv.2006.01.004
- Cheng JQ, Lindsley CW, Cheng GZ, et al: The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene 2005;24(50): 7482-7492 https://doi.org/10.1038/sj.onc.1209088
- MacKeigan JP, Taxman DJ, Hunter D, et al: Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of Taxol and mitogen-activated protein kinase inhibition. Clin Cancer Res 2002;8(7):2091-2099
- Hu L, Hofmann J, Lu Y, et al: Inhibition of phosphatidylinositol 30-kinase increases efficacy of paclitaxel in vitro and in vivo ovarian cancer models. Cancer Res 2002;62(4):1087-1092
- Shingu T, Yamada K, Hara N, et al: Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoin- ositide 3-kinase inhibitor in human malignant glioma cells. Cancer Res 2003;63(14):4044-4047
- Schultz RM, Merriman RL, Andis SL, et al: In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin. Anticancer Res 1995;15:1135-1139
- Price BD, Youmell MB: The phosphatidylinositol 3-kinase inhibitor wortmannin sensitises murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage. Cancer Res 1996;56:246-250
- Davol PA, Bizuneh A, Frackelton AR Jr.: Wortmannin, a phosphoinositide 3-kinase inhibitor, selectively enhances cytotoxicity of receptor-directed-toxin chimeras in vitro and in vivo. Anti-cancer Res 1999;19:1705-1713
- Lemke LE, Paine-Murrieta GD, Taylor CW, Powis G: Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase. Cancer Chemother Pharmocol 1999;44:491-497 https://doi.org/10.1007/s002800051123
- Amornphimoltham P, Sriuranpong V, Patel V, et al: Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01. Clin Cancer Res 2004;15;10(12 Pt 1):4029-37
- Roymans D, Slegers H: Phosphatidylinositol 3-kinases in tumor progression. Eur J Biochem 2001;268:487-498 https://doi.org/10.1046/j.1432-1327.2001.01936.x
- Li Y, Podsypanina K, Liu X, et al: Deficiency of pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice. BMC Mol Biol 2:2. doi: 10.1186/1471-2199-2-2, 2001
- Weng LP, Brown JL, Eng C: PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways. Hum Mol Genet 2001;10:237-242 https://doi.org/10.1093/hmg/10.3.237
- Stefania Morrone: ANNEXIN V in 'Purdue Cytometry CD-ROM Series,volume 4'. Dept. Experimental Medicine & Pathology, University 'La Sapienza', Rome, Italy
- Vermes I, Haanen C, Steffens-Nakken H, et al : A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 1995;17;184(1):39-51
- Rowinsky E: The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents. Annu Rev Med 1997; 48:353374
- Sharon L. Schendel, Zhihua Xie, Myrta Oblatt Montal, et. al.: Channel formation by antiapoptotic protein Bcl-2, Proc Natl Acad Sci USA 1997;13;94(10):5113-5118
- Ciechomska I, Pyrzynska B, Kazmierczak, et al: Signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cell. Oncogene 2003;23:22(48): 7616-27
- Bustamante J, Caldes Lopes E, Garcia M, et al: Disruption of mitochondrial membrane potential during apoptosis induced by Psc 833 and CsA in multidrug resistant lymphoid leukemia. Toxicol Appl Pharmacol 15 190(1):44-51 https://doi.org/10.1016/j.taap.2004.03.021
- Igarashi K, Hirotani H, Woo JT, et al.: Cyclosporin A and Fk506 induce osteoclast apoptosis in mouse bone marrow cell cultures. Bone 2004;35(1):47-56 https://doi.org/10.1016/j.bone.2004.02.009
- Kruijtzer CM, Schellens JH, Mezger J, et al.: Phase II and pharmacologic study of weakly oral paclitaxel plus cyclosporine in patients with advanced non-small-cell lung cancer. J Clin Oncol 2002;20(23);4508-4516 https://doi.org/10.1200/JCO.2002.04.058
- Nomura T, Yamamoto H, Mimata H, et al.: Enhancement by cyclosporin A of taxol-indeced apoptosis of human urinary bladder cancer cells. Urol Res 2002;30(2):102-111 https://doi.org/10.1007/s00240-002-0239-4
- Kemper Em, van Zandberger Ae, Cleypool C, et al.: Increased penetration of paclitaxel into the brain by inhibition of P-glycoprotein. Clin Cancer Res 2003;9(7):2849-2855
- Bardelimeijer HA, Ouwehand M, Meijnen JH, et al.: Efficacy of novel p-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice. Invest New Drug 2004;22(3):219-229 https://doi.org/10.1023/B:DRUG.0000026248.45084.21
- Torres K, Horwitz SB: Mechanism of Taxol-induced cell death are concentration dependent. Cancer Res 1998;58:3620-3626