Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제33권5호
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  • Pages.419-425
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  • 2007
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
권호 표지

나노 에멀젼이 잇몸 염증의 예방 및 치료에 미치는 효과에 대한 연구

THE STUDY ON THE EFFECT OF NANOEMULSION FOR THE PREVENTION AND TREATMENT OF GINGIVAL INFLAMMATION

  • 채창훈 (나노큐어텍 나노-바이오 퓨전 부설연구소) ;
  • 박준우 (한림대학교 의과대학 구강악안면외과학교실)
  • Chae, Chang-Hoon (Institute of Nano-Bio Fusion Technology, NanoCureTech Inc) ;
  • Park, Jun-Woo (Dept. of Oral and Maxillofacial Surgery, College of Medicine, Hallym University)
  • 발행 : 2007.10.31
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초록

We have found out the relationship of nanoemulsion containing nano vitamin C, E and propolis and gingival disease. We've confirmed effect of nanoemulsion through the experiment of in vivo and in vitro. We tested cell viability of gingival fibroblast cells by MTT assay and mRNA appearance of interleukin-$1{\beta}$, using mouse that was guided inflammation. Anti-microbacterial activity for Antibacterial effect's experiment was carried out by using S.aureus and E.coli. In addition, inflammation tissue has been observed with scanning electrical microscopy. In this study, expression of interleukin-$1{\beta}$ was decreased after adding nanoemulsion containing nanovitamin C, E and propolis. We've also obtained good results from the test of Antibacterial effect against S.aureus and E.coli. Also, swelling of inflammation tissues observed by scanning electrical microscopy has gone down. In conclusion, we have gained confidence that nanoemulsion containing nano vitamin C, E and propolis has very high Antibacterial effect against bacteria in oral. And it made us guess that inflammation of gingival reduces after decreasing interleukin-$1{\beta}$. Thus, we expect that nanoemulsion containing nano vitamin C, E and propolis gives good effects to patient having gingival disease.

키워드

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