대한한의학방제학회지 (Herbal Formula Science)

  • 제15권2호
  • /
  • Pages.89-98
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  • 2007
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  • 1229-1218(pISSN)
  • /
  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
권호 표지

균기산(勻氣散)이 흰쥐의 국소뇌혈류량 및 평균혈압에 미치는 효과

Effect of Kyungisan in on the Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats

  • 정종안 (동신대학교 한의과대학 내과학교실) ;
  • 홍석 (동신대학교 한의과대학 내과학교실) ;
  • 전상윤 (동신대학교 한의과대학 내과학교실)
  • Jung, Jong-An (Department of Internal Medicine, College of Oriental Medicine, Dongshin University) ;
  • Hong, Seok (Department of Internal Medicine, College of Oriental Medicine, Dongshin University) ;
  • Jun, Sang-Yun (Department of Internal Medicine, College of Oriental Medicine, Dongshin University)
  • 발행 : 2007.12.30
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초록

Kyungisan (KGS) has been used in oriental medicine for many centuries as a therapeutic agent for treatment of stroke caused by deficiency of qi(氣虛). This study was performed to evaluate effects of KGS extract on the regional cerebral blood flow(rCBF) and mean arterial blood pressure(MABP) in rats. The result of this study were as follow ; 1. KGS significantly increased rCBF irrelevant to MABP in normal rats, 2. To prescribe KGS after pretreatment with indomethacin(IDN) decreased rCBF as compared with control group to administered only KGS in normal rats. But the change of MABP is not significantly as compared with control group. 3. To prescribe KGS after pretreatment with methylen blue( MTB) decreased MABP and rCBF as compared with control group to administered only KGS in normal rats. Especially, it significantly decreased rCBF. These results suggest that KGS increase rCBF by enlargement diameter of pial artery in brain. The active mechanism of KGS is related with prostaglandin activated by cyclooxygenase. So, I suggest that KGS has an anti-ischemic effect through the improvement of cerebral blood flow and can be used for stroke.

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