대한본초학회지 (The Korea Journal of Herbology)
- 제22권4호
- /
- Pages.239-245
- /
- 2007
- /
- 1229-1765(pISSN)
- /
- 2288-7199(eISSN)
단삼(丹蔘)이 고지혈증 흰쥐의 혈중 지질 변화에 미치는 영향
Effects of Salviae miltiorrhizae Radix (SMR) on Serum Lipid Level in Hyperlipidemic Rats
- 김형철 (동의대학교 한의과대학) ;
- 김형우 (동신대학교 한의과대학) ;
- 김용성 (동신대학교 한의과대학) ;
- 이장식 (동신대학교 한의과대학) ;
- 권정남 (동의대학교 한의과대학) ;
- 김영균 (동의대학교 한의과대학) ;
- 조수인 (동신대학교 한의과대학)
- Kim, Hyeong-Cheol (College of Korean medicine, Dong-Eui University) ;
- Kim, Hyung-Woo (College of Korean medicine, Dongshin University) ;
- Kim, Yong-Seong (College of Korean medicine, Dongshin University) ;
- Lee, Jang-Sik (College of Korean medicine, Dongshin University) ;
- Kwon, Jeong-Nam (College of Korean medicine, Dong-Eui University) ;
- Kim, Young-Gyun (College of Korean medicine, Dong-Eui University) ;
- Cho, Su-In (College of Korean medicine, Dongshin University)
- 발행 : 2007.12.31
초록
Objective : Salviae miltiorrhizae Radix (SMR) has widely used to treat patients with cardiovascular diseases such as coronary arteriosclerosis, angina pectoris and hyperlipidemia. This study was designed to investigate the effects of SMR on changes in serum cholesterol and protective effects on liver tissue damage in Hyperlipidemic rats. Methods : The present author investigated changes in serum glucose, cholesterols, AST/ALT and histopathological changes of liver tissue by oral administration of SMR in Rats. Results : In this study, body weights of hyperlipidemic rats induced high fat diet did not changed, and treatment with SMR did not affect body weights in hyperlipidemic rats. For experimental period, Food and Water uptake in SMR administered group were the same as those in hyperlipidemic control group. In this experiment, treatment with SMR decreased total cholesterol and AST in serum which elevated by high fat diet respectively. In addition, SMR administration protected liver tissue from damage induced by induction of hyperlipidemia. Conclusions: These results suggest that SMR is useful to treat patients with disease related to cardiovascular diseases including hyperlipidemia, because SMR can decrease cholesterol and AST in serum and also have non-specific protective effect on tissues including liver.