Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Different Pattern of p27kip1 and p21cip1 Expression Following Ex Vivo Activation of CD8+ T Lymphocytes

  • Kim, Sung-Jin (Department of Pharmacology, Institute of Oral Health, School of Dentistry, Kyung Hee University) ;
  • Lee, Hyeon-Woo (Department of Pharmacology, Institute of Oral Health, School of Dentistry, Kyung Hee University)
  • Published : 2007.12.31
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Abstract

T cell proliferation is a pivotal to an effective immune response. Cyclin-dependent kinase (cdk) inhibitor, $p27^{kip1}$ is degraded to initiate T cell expansion. In this study, we show that although the expression of $p27^{kip1}$ protein was down-regulated, that of $p21^{cip1}$, another cdk inhibitor, was up-regulated in $CD8^+$ T cells following in vitro stimulation. Ex vivo gB antigen-stimulation following HSV immunization increased $p21^{cip1}$ positive cells that co-expressed IFN-$\gamma$. Moreover, $p21^{cip1}$ was co-expressed with IFN-${\gamma}$ in E7 antigen-stimulated $CD8^+$ T cells, whereas $p27^{kip1}$ was not. Our findings imply a role of $p21^{cip1}$ proteins in antigen-induced effector $CD8^+$ T cells differentiation in vivo.

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References

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