대한의생명과학회지 (Biomedical Science Letters)
- 제13권4호
- /
- Pages.313-317
- /
- 2007
- /
- 1738-3226(pISSN)
- /
- 2288-7415(eISSN)
Effect of Ailanthi Radicis Cortex Extracts on Melanogenesis
-
조영호
(건양대학교 제약공학과)
-
Cho, Young-Ho
(Department of Pharmaceutical Engineering, Konyang University)
- 발행 : 2007.12.31
초록
Melanogenesis refers to the biosynthesis of melanin pigment in melanocytes. Melanogenesis is controlled by the intra- and extracellular environments. In the present study, to develop a new whitening agent, it was investigated the antioxidant activity and the inhibitory effect of Ailanthi Radicis Cortex extract on tyrosinase activity and on melanogenesis in the B16/F1 melanoma cells. The inhibition ratio of tyrosinase activity of ethylacetate fraction from Ailanthi Radicis Cortex was higher than that of arbutin. The ethylacetate fraction showed scavenging activities of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and superoxide anion radicals in a dose dependent manner. The highest inhibitory activity of melanogenesis was also in ethylacetate fraction (