대한의생명과학회지 (Biomedical Science Letters)
- 제13권4호
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- Pages.279-285
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- 2007
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Role of Retinoic Acid in Spontaneous Apoptosis of Human Neutrophils
- Yang, Eun-Ju (Department of Biomedical Laboratory Science, School of Medicine, Eulji University) ;
- Lee, Ji-Sook (Department of Biology, College of Natural Sciences, Daejeon University) ;
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Kim, Dong-Hee
(Department of Pathology, College of Oriental Medicine, Daejeon University) ;
- Min, Bok-Kee (Department of Biomedical Laboratory Science, School of Medicine, Eulji University) ;
- Hyun, Sung-Hee (Department of Biomedical Laboratory Science, School of Medicine, Eulji University) ;
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Kim, In-Sik
(Department of Biomedical Laboratory Science, School of Medicine, Eulji University)
- 발행 : 2007.12.31
초록
Although retinoic acid has been known as either anti-inflammatory or pro-inflammatory molecule, depending on the cell type, its exact role in mature human neutrophils has not been fully explored. In this study, we investigate the effects of retinoic acid on neutrophil apoptosis and the associated mechanism and found that 9-cis retinoic acid (9CRA) significantly inhibits the spontaneous apoptosis of neutrophils. Its effect is increased by co-treatment with