대한세포병리학회지 (The Korean Journal of Cytopathology)

대한세포병리학회 (The Korean Society for Cytopathology)
권호 표지

갑상샘 유두암을 닮은 전이성 흑색종의 세침 흡인 세포 소견 -1예 보고-

Metastatic Melanoma Mimicking a Papillary Carcinoma of the Thyroid in Fine Needle Aspiration Cytology -A Case Report-

  • 홍영옥 (울산의대 서울아산병원 병리과) ;
  • 서재희 (울산의대 울산대학교병원 병리과) ;
  • 차희정 (울산의대 울산대학교병원 병리과) ;
  • 최혜정 (울산의대 울산대학교병원 병리과) ;
  • 김영민 (울산의대 울산대학교병원 병리과)
  • Hong, Young-Ok (Department of Pathology, Ulsan University Hospital, Ulsan and Asan Medical Center) ;
  • Suh, Jae-Hee (Department of Pathology, University of Ulsan College of Medicine) ;
  • Cha, Hee-Jeong (Department of Pathology, University of Ulsan College of Medicine) ;
  • Choi, Hye-Jeong (Department of Pathology, University of Ulsan College of Medicine) ;
  • Kim, Young-Min (Department of Pathology, University of Ulsan College of Medicine)
  • 발행 : 2007.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Metastasis to the thyroid gland is very rare in clinical practice. We recently encountered a 65-year-old woman who presented with a large thyroid nodule that mimicked the cytologic features of a papillary thyroid carcinoma on fine needle aspiration biopsy (FNAB). Although initially diagnosed as a papillary thyroid carcinoma, a thorough clinical work-up revealed multiple lesions in the bones, liver, and nasal cavity, which were confirmed as metastases of a malignant melanoma. Despite a thorough physical examination, however, the primary skin lesion could not be identified. Although FNAB shows a high degree of accuracy in diagnosing primary thyroid tumors, it is less accurate in diagnosing metastases to the thyroid gland. A thorough clinical history with appropriate immunohistochemical staining assays is necessary for the accurate diagnosis of metastatic malignant melanoma.

키워드

참고문헌

  1. Gerges AS, Shehata SR, Gouda IA. Metastasis to the thyroid gland; unusual site of metastasis. J Egypt Natl Canc Inst 2006;18:67-72
  2. Koss LG, Woyke S, Olszewski W. Aspiration Biopsy: Cytologic Interpretation and Histology Base. New York: Igaku-Shoin, 1984;154-90
  3. Lowhagen T, Willems JS. Aspiration biopsy cytology in diseases of thyroid. In: Koss LG, Coleman DV. Advances in Clinical Cytology. London; Butterworth, 1981;201-31
  4. Sheppard BC, Moseley HS. Malignant melanoma metastatic to the thyroid as initial evidence of disseminated disease. J Surg Oncol 1990;43:196-8 https://doi.org/10.1002/jso.2930430315
  5. Patel JK, Didolkar MS, Pickren JW, Moore RH. Metastatic pattern of malignant melanoma. A study of 216 autopsy cases. Am J Surg 1978;135:807-10 https://doi.org/10.1016/0002-9610(78)90171-X
  6. Haugen BR, Nawaz S, Cohn A, et al. Secondary malignancy of the thyroid gland: a case report and review of the literature. Thyroid 1994;4:297-300 https://doi.org/10.1089/thy.1994.4.297
  7. Bozbora A, Barbaros U, Kaya H, et al. Thyroid metastasis of malignant melanoma. Am J Clin Oncol 2005;28:642-3 https://doi.org/10.1097/01.coc.0000159560.52040.18
  8. Miiji LO, Nguyen GK. Metastatic melanoma of the thyroid mimicking a papillary carcinoma in fine-needle aspiration. Diagn Cytopathol 2005;32:374-6 https://doi.org/10.1002/dc.20261
  9. Suh JH, Huh JR, Gong GY. Cytologic features of metastatic melanoma. Korean J Cytopathol 1996;7:185-91
  10. Perry MD, Gore M, Seigler HF, Johnston WW. Fine needle aspiration biopsy of metastatic melanoma: a morphologic analysis of 174 cases. Acta Cytol 1986;30:385-96
  11. Eftekhari F, Peuchot M. Thyroid metastases: combined role of ultrasonography and fine needle aspiration biopsy. J Clin Ultrasound 1989;17:657-60 https://doi.org/10.1002/jcu.1870170908
  12. Oertel YC. Thymoma mimicking thyroid papillary carcinoma: another pitfall in fine-needle aspiration. Diagn Cytopathol 1997;17:61-3 https://doi.org/10.1002/(SICI)1097-0339(199707)17:1<61::AID-DC13>3.0.CO;2-8
  13. Baab GH, McBride CM. Malignant melanoma: the patient with an unknown site of primary origin. Arch Surg 1975;110:896-900 https://doi.org/10.1001/archsurg.1975.01360140040008
  14. Karakousis CP, Moore R, Holyoke ED. Surgery in recurrent malignant melanoma. Cancer 1983;52:1342-5 https://doi.org/10.1002/1097-0142(19831001)52:7<1342::AID-CNCR2820520733>3.0.CO;2-C