유방에 생긴 과립세포종양의 세포 소견 -1예 보고-

Fine Needle Aspiration Cytology of Granular Cell Tumor in Breast -A Case Report-

  • 정수영 (한국원자력의학원 원자력병원 병리과) ;
  • 노우철 (한국원자력의학원 원자력병원 일반외과) ;
  • 진민선 (한국원자력의학원 원자력병원 병리과) ;
  • 이승숙 (한국원자력의학원 원자력병원 병리과) ;
  • 고재수 (한국원자력의학원 원자력병원 병리과)
  • Chung, Soo-Young (Department of Pathology, Korea Cancer Center Hospital, KlRAMS) ;
  • Noh, Wo-Chul (Department of General Surgery, Korea Cancer Center Hospital, KlRAMS) ;
  • Jin, Min-Sun (Department of Pathology, Korea Cancer Center Hospital, KlRAMS) ;
  • Lee, Seung-Sook (Department of Pathology, Korea Cancer Center Hospital, KlRAMS) ;
  • Koh, Jae-Soo (Department of Pathology, Korea Cancer Center Hospital, KlRAMS)
  • 발행 : 2007.09.30

초록

Granular cell tumor (GCT) of the breast is a rare clinical entity, and is believed to be of schwannian origin and to follow a benign clinical course. A 50-year-old woman presented with a slowly growing mass in the right breast. Fine needle aspiration cytology revealed a cellular smear containing isolated or clustered cells showing round to oval nuclei with abundant oncocytic granular cytoplasm. Nuclei showed a fine granular chromatin pattern and occasional small single nucleoli. Cell boundaries were poorly defined, and naked nuclei were frequently found, Histologically, the tumor showed features of typical GCT, and immunohistochemical staining findings strongly supported the diagnosis. The present study demonstrates that GCT of the breast can mimic malignant lesions of breast both clinically and radiologically. The recognition of its cytologic features and suspicion of this lesion would undoubtedly aid the correct diagnosis of mammary GCT.

키워드

참고문헌

  1. Abrikossoff A. Uber myome, ausgehend von der quergestreiften, willkurlichen muskulatur. Virchows Arch Pathol Anat 1926;260:215-33 https://doi.org/10.1007/BF02078314
  2. Adeniran A, Al-Ahmadie H, Mahoney MC, Robinson-Smith TM. Granular cell tumor of the breast: a series of 17 cases and review of the literature. Breast J 2004;10:528-31 https://doi.org/10.1111/j.1075-122X.2004.21525.x
  3. Lack EE, Worsham GF, Callihan MD, et al. Granular cell tumor: a clinicopathologic study of 110 patients. J Surg Oncol 1980;13:301-16 https://doi.org/10.1002/jso.2930130405
  4. Akatsu T, Kobayashi H, Uematsu S, et al. Granular cell tumor of the breast preoperatively diagnosed by fine-needle aspiration cytology: report of a case. Surg Today 2004;34:760-3
  5. Liu K, Madden JF, Olatidoye BA, Dodd LG. Features of benign granular cell tumor on fine needle aspiration. Acta Cytol 1999;43:552-7 https://doi.org/10.1159/000331146
  6. Hahn HJ, Iglesias J, Flenker H, Kreuzer G. Granular cell tumor in differential diagnosis of tumors of the breast. The role of fine needle aspiration cytology. Pathol Res Pract 1992;188:1091-7 https://doi.org/10.1016/S0344-0338(11)81258-6
  7. Kim EK, Lee MK, Oh KK. Granular cell tumor of the breast. Yonsei Med J 2000;41:673-5 https://doi.org/10.3349/ymj.2000.41.5.673
  8. Kim SY, Hwang JS, Kwon HP, Yang JH, Roh JS, Yang WS. Fine needle aspiration cytology of granular cell tumor of the lower leg: report of a case. Korean J Cytopathol 2004;15:126-30
  9. Oh MH, Khang SK. Fine needle aspiration cytology of granular cell tumor of the thigh. A case report. Korean J Cytopathol 1993;4:66-9
  10. McCluggage WG, Sloan S, Kenny BD, Alderdice JM, Kirk SJ, Anderson NH. Fine needle aspiration cytology (FNAC) of mammary granular cell tumour. a report of three cases. Cytopathology 1999;10:383-9 https://doi.org/10.1046/j.1365-2303.1999.00201.x
  11. Gibbons D, Leitch M, Coscia J, et al. Fine needle aspiration cytology and histologic findings of granular cell tumor of the breast: review of 19 cases with clinical/radiologic correlation. Breast J 2000;6:27-30 https://doi.org/10.1046/j.1524-4741.2000.99017.x
  12. Jayaram G, Hoon PB, Har YC. Granular cell tumor of breast: diagnosis by fine needle aspiration cytology. Acta Cytol 2006;50:593-5 https://doi.org/10.1159/000326024
  13. Pieterse AS, Mahar A, Orell S. Granular cell tumour: a pitfall in FNA cytology of breast lesions. Pathology 2004;36:58-62 https://doi.org/10.1080/00313020310001646640
  14. Placidi A, Aversa A, Foggi CM, Foggi P, Ricci G, Salvatori V. Granular cell tumour of breast in a young man preoperatively diagnosed by fine needle aspiration (FNA) Cytology. Cytopathology 1995;6:343-8 https://doi.org/10.1111/j.1365-2303.1995.tb00581.x