Food Science and Biotechnology

  • 제16권6호
  • /
  • Pages.1046-1050
  • /
  • 2007
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  • 1226-7708(pISSN)
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  • 2092-6456(eISSN)
한국식품과학회 (Korean Society of Food Science and Technology)
권호 표지

An Herbal Medicine Mixture (HM-10) Induces Longitudinal Bone Growth and Growth Hormone Release in Rats

  • Park, Sung-Sun (Department of Food and Nutrition, Sungshin Women's University) ;
  • Oh, Sung-Hoon (Department of Food Engineering, Ansan College of Technology) ;
  • Bae, Song-Hwan (Department of Food and Biotechnology, Hankyong National University) ;
  • Kim, Jung-Min (Department of Radiologic Science, Korea University) ;
  • Chang, Un-Jae (Department of Food and Nutrition, Dongduk Women's University) ;
  • Park, Jung-Min (Department of Food Science and Biotechnology of Animal Resources, Konkuk University) ;
  • Kim, Jin-Man (Department of Food Science and Biotechnology of Animal Resources, Konkuk University) ;
  • Suh, Hyung-Joo (Department of Food and Nutrition, Korea University)
  • 발행 : 2007.12.31
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초록

To investigate the growth promoting effects of an herbal medicine formulation (HM-10), Sprague Dawley (SD) male rats (3 weeks old) were divided into 3 groups (8 rats/group). The control group was given a daily oral administration of saline, and the treatment groups, HM-1 and HM-2, were given daily administrations of HM-10 (500 and 1,000 mg/kg BW, respectively). The cumulative tibial bone growth of the HM-1 and HM-2 groups (22.5 and 20.8 mm, respectively), and their cumulative femur bone growth (19.4 and 18.2 mm, respectively), were significantly different compared to the control group (7.5 mm of tibial growth and 7.7 mm of femur growth) (p<0.05). Lastly, the growth hormone levels of the HM-1 and HM-2 groups (1.70 and 1.79 ng/mL, respectively), as well as their insulin like growth factor 1 (IGF-1) levels (165.1 and 171.7 ng/mL, respectively) showed significant differences compared to the control (0.93 ng/mL of growth hormone and 125.6 ng/mL of IGF-1) (p<0.05).

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