Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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The Association of Insulin Resistance with Cardiovascular Disease Risk and Dietary Factors in Korean Type 2 DM Patients

제2형 당뇨병 환자에서 인슐린저항성과 심혈관질환 위험요인 및 식이요인과의 관계

  • Yu, So-Young (Department of Food and Nutrition, Ewha Womans University) ;
  • Hong, Hye-Sook (Department of Food and Nutrition, Ewha Womans University) ;
  • Lee, Hyun-Sook (Department of Sports Science, Seoul Sports Graduate University) ;
  • Choi, Young-Ju (21C Diebetics and Vascular Research Center) ;
  • Huh, Kap-Bum (21C Diebetics and Vascular Research Center) ;
  • Kim, Wha-Young (Department of Food and Nutrition, Ewha Womans University)
  • 유소영 (이화여자대학교 식품영양학과) ;
  • 홍혜숙 (이화여자대학교 식품영양학과) ;
  • 이현숙 (서울스포츠대학원대학교) ;
  • 최영주 (21세기 당뇨병 혈관 연구소) ;
  • 허갑범 (21세기 당뇨병 혈관 연구소) ;
  • 김화영 (이화여자대학교 식품영양학과)
  • Published : 2007.01.31
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Abstract

The purpose of this study was to investigate the association between insulin resistance and cardiovascular disease risk factors in Korean type 2 diabetes patients. The subjects were 429 (male: 218, female: 211) type 2 DM patients visited DM clinic, and they were classified into quartiles based on $K_{ITT}$ index (%/min, Insulin Tolerance Test). Anthropometric and biochemical characteristics, and dietary intakes by Food Frequency Questionnaire were assessed. The means of waist circumference, fat mass, percent body fat and abdominal fat thickness were significantly higher in the lowest quartile (the most insulin resistant group) than in the highest quartile (the least insulin resistant group) of $K_{ITT}$ index (%/min)(p<0.05), For hematological values, the lowest quartile showed significantly higher fasting blood glucose, HbA1c, C-peptide, insulin, triglyceride, ApoB/apoA-1 ratio and C-reactive protein compared to the highest quartile (p < 0.05). Moreover, $K_{ITT}$ index (%/min) was negatively correlated with waist circumference, fat mass, percent body fat, abdominal fat thickness and fasting blood concentrations of glucose, HbA1c, C-peptide, insulin, cholesterol, triglyceride, ApoB/apoA-1 ratio and C-reactive protein (p < 0.05). Nutrient intakes were not significantly different among the quartile groups of $K_{ITT}$ index (%/min) and also not correlated with insulin resistance, however, they showed correlation with obesity parameters (BMI, waist circumference, waist-hip ratio, vat mass, abdominal fat thickness), which were strongly associated with insulin resistance. In conclusion, cardiovascular disease risk would be higher as the insulin resistance grows in Korean type 2 DM patients, and nutrient intakes would affect to the insulin resistance through the effect on anthropometric parameters.

Keywords

References

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