Journal of Chest Surgery

The Korean Society for Thoracic and Cardiovascular Surgery (대한심장혈관흉부외과학회)
권호 표지

Surgical Management of Invasive Pulmonary Aspergillosis in Hemtologic Malignancy Patients - Report of 2 cases -

혈액종양 질환 환자에서 발생한 침습성 폐 국균증의 수술적 치료 - 2예 보고 -

  • Beom, Min-Sun (Department of Thoracic and Cardiovascular Surgery, Chonnam National University Hospital) ;
  • Song, Sang-Yun (Department of Thoracic and Cardiovascular Surgery, Chonnam National University Hospital) ;
  • Kim, Byong-Pyo (Department of Thoracic and Cardiovascular Surgery, Chonnam National University Hospital) ;
  • Park, Jeong-Min (Department of Thoracic and Cardiovascular Surgery, Chonnam National University Hospital) ;
  • Lee, Kyo-Seon (Department of Thoracic and Cardiovascular Surgery, Chonnam National University Hospital) ;
  • Na, Kook-Joo (Department of Thoracic and Cardiovascular Surgery, Chonnam National University Hospital)
  • 범민선 (전남대학교병원 흉부외과) ;
  • 송상윤 (전남대학교병원 흉부외과) ;
  • 김병표 (전남대학교병원 흉부외과) ;
  • 박정민 (전남대학교병원 흉부외과) ;
  • 이교선 (전남대학교병원 흉부외과) ;
  • 나국주 (전남대학교병원 흉부외과)
  • Published : 2007.01.05
Download PDF
⟨ Previous Next ⟩

Abstract

The mortality rate of the invasive pulmonary aspergillosis to be able to developed during chemotherapy induced myleosuppressionin is high in hematologic malignancy patients despite antifungal treatment. Effective antifungal treatment combined with operation can decrease the mortaligy rate of the invasive pulmonary aspergillosis. Recently, we experienced the successful management of the two cases of invasive pulmonary aspergillosis in acute lymphoblastic leukemia through effective antifungal treatment and surgical resection. We report this cases with review of literature.

혈액종양 질환 환자에서 항암요법에 의한 골수기능 저하상태에서 발생할 수 있는 침습성 폐 국균증은 항진균제의 사용에도 불구하고 사망률이 높다. 적절한 항진균제의 사용과 함께 수술적 절제가 침습성 폐 국균증의 사망률을 낮출 수 있다고 보고되고 있다. 최근 저자들은 급성 림프구성 백혈병으로 진단된 환아 2명에서 침습성 폐 국균증을 효과적인 항진균제와 함께 수술적 절제를 통해 치료하여 좋은 결과를 치험하였다. 이에 문헌고찰과 함께 보고하는 바이다.

Keywords

References

  1. Denning DW, Stevens DA. Antifungal and surgical treatment of invasive aspergillosis: review of 2121 published cases. Rev Infect Dis 1990;12:1147-201 https://doi.org/10.1093/clinids/12.6.1147
  2. Pagano L, Ricci P, Nosari A, et al. Fatal haemoptysis in pulmonary filamentous mycosis: an underevaluated cause of death in patient with acute leukemia in hematological complete remission. A retrospective study and review of literature. Br J Haematol 1995;89:500-5 https://doi.org/10.1111/j.1365-2141.1995.tb08355.x
  3. Bernard A, Caillot D, Couaillier JF, et al. Surgical management of invasive pulmonary aspergillosis in neutropenic patients. Ann Thorac Surg 1997;64:1441-7 https://doi.org/10.1016/S0003-4975(97)00858-8
  4. Hatley RM, Donaldson JS, Raffensperger JG. Splenic micro-abscesses in the immunecompromised patient. J Pediatr Surg 1989;24:697-9 https://doi.org/10.1016/S0022-3468(89)80723-7
  5. Caillot D, Casasnovas O, Bernard A, et al. Improved management of invasive pulmonary aspergillosis in neutropenic patients using systemic early thoracic CT-scan and surgery. J Clin Oncol 1997;15:139-47 https://doi.org/10.1200/JCO.1997.15.1.139
  6. Przyjemski C, Mattii R. The formation of pulmonary mycetoma. Cancer 1980;46:1701-4 https://doi.org/10.1002/1097-0142(19801001)46:7<1701::AID-CNCR2820460733>3.0.CO;2-4
  7. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med 1989;6:365-76