Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Hangbisan, Sulfur-based Oriental Medicine, Lowers the Blood Cholesterol Level of ob/ob Obese Mice

유전성 비만 마우스에 대한 항비산의 혈중 콜레스테롤 저하 효과

  • Chae, Myoung-Hee (Dept. of Food and Nutrition and Human Ecology Research Institute, Chonnam National University) ;
  • No, Jin-Gu (Baek-du Oriental Medicine Center) ;
  • Jhon, Deok-Young (Dept. of Food and Nutrition and Human Ecology Research Institute, Chonnam National University)
  • 채명희 (전남대학교 식품영양학과, 생활과학연구소) ;
  • 노진구 (광주 백두한의원) ;
  • 전덕영 (전남대학교 식품영양학과, 생활과학연구소)
  • Published : 2007.01.31
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Abstract

Among oriental medicine, sulfur is known to generate heat in the human body. Since body warming reaction results in the consumption of energy source, the medicines containing sulfur could help in the weight loss of laboratory rats. This study was designed to determine the possible weight loss effects of Hangbisan, sulfur based oriental medicine, on ob/ob mice. The obese mice were fed with standard diet containing 10% (w/w) Hangbisan or 10% (w/w) cellulose during 12 weeks. Hangbisan affected the weight loss of obese mice as cellulose did during experimental periods, while also reducing the level of plasma total cholesterol. These results suggest that dietary Hangbisan improved the composition of blood profiles in obese mice, and therefore has potential as an anti-obesity ingredient in the application of oriental medicine compounds.

한약에서 사용하는 유황은 인체에서 열을 발생하는 물질로서 분류되어 있다. 차전자(車前子), 창출(蒼朮), 백복령, 천궁(川芎) 등은 비만을 치료하는 한약재로 이용되고 있다. 본 연구에서는 유황을 주성분으로 하고 차전자(車前子), 창출(蒼朮), 백복령, 천궁 등의 한약재를 혼합한 항비산을 제조하였다. 항비산을 10%(w/w) 함유한 식이를 C57BL/6J ob/ob mice에 12주 동안 투여하고 체중, 간 조직 및 혈액 지질 조성에 미치는 효과를 조사하였다. 유황이 주로 함유된 항비산을 섭취하는 동안 실험동물의 건강상태는 양호하였다. 항비산을 일반 식이와 병행 공급시 cellulose가 갖는 정도의 체중 감소 효과를 나타냈고, 혈중 총 콜레스테롤이 감소하여 혈중 지질 조성을 개선시키는 작용이 있었다. 또한 실험동물의 간 기능에는 독성을 나타내지 않았다. 따라서 항비산의 임상실험 및 지질 조성 개선 효과에 대한 기전연구가 필요하지만 항비산은 비만인의 체중감량 및 지질 조성 개선에 이용될 수 있을 것으로 사료된다.

Keywords

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