Multiple Spinal Intramedullary Cavernous Malformation with Multiple Intracranial Involvement

  • Cho, Jae-Ik (Department of Neurosurgery Daegu Catholic University School of Medicine) ;
  • Cho, Young-Dae (Department of Neurosurgery Daegu Catholic University School of Medicine) ;
  • Kim, Young-Don (Department of Neurosurgery Daegu Catholic University School of Medicine)
  • Published : 2007.07.30

Abstract

Intraspinal cavernous malformation (CM) accounts for 5% to 16% of all spinal vascular abnormalities. Multiple spinal cord CMs are very rare and only a few cases have been described. We report a patient presented with right chest paresthesia and seizure, and diagnosed as multiple spinal intramedullary CM and intracranial involvement.

Keywords

References

  1. Anson JA, Spetzler RF : Surgical resection of intramedullary spinal cord cavernous malformations. J Neurosurg 78 : 446-451, 1993 https://doi.org/10.3171/jns.1993.78.3.0446
  2. Awad IA, Robinson JR Jr, Mohanty S, Estes ML : Mixed vascular malformations of the brain : clinical and pathogenetic considerations. Neurosurgery 33 : 179-188; discussion 188, 1993 https://doi.org/10.1227/00006123-199308000-00001
  3. Bicknell JM, Carlow TJ, Kornfeld M, Stovring J, Turner P : Familial cavernous angiomas. Arch Neurol 35 : 746-749, 1978 https://doi.org/10.1001/archneur.1978.00500350050010
  4. Canavero S, Pagni CA, Duca S, Bradac GB : Spinal intramedullary cavernous angiomas : a literature meta-analysis. Surg Neurol 41 : 381- 388, 1994 https://doi.org/10.1016/0090-3019(94)90031-0
  5. Cohen-Gadol AA, Jacob JT, Edwards DA, Krauss WE : Coexistence of intracranial and spinal cavernous malformations : a study of prevalence and natural history. J Neurosurg 104 : 376-381, 2006 https://doi.org/10.3171/jns.2006.104.3.376
  6. Cosgrove GR, Bertrand G, Fontaine S, Robitaille Y, Melanson D : Cavernous angiomas of the spinal cord. J Neurosurg 68 : 31-36, 1988 https://doi.org/10.3171/jns.1988.68.1.0031
  7. Deutsch H, Shrivistava R, Epstein F, Jallo GI : Pediatric intramedullary spinal cavernous malformations. Spine 26 : E427-431, 2001 https://doi.org/10.1097/00007632-200109150-00023
  8. Dubovsky J, Zabramski JM, Kurth J, Spetzler RF, Rich SS, Orr HT, et al : A gene responsible for cavernous malformations of the brain maps to chromosome 7q. Hum Mol Genet 4 : 453-458, 1995 https://doi.org/10.1093/hmg/4.3.453
  9. Graziani N, Bouillot P, Figarella-Branger D, Dufour H, Peragut JC, Grisoli F : Cavernous angiomas and arteriovenous malformations of the spinal epidural space : report of 11cases. Neurosurgery 35 : 856- 863; discussion 863-864, 1994 https://doi.org/10.1227/00006123-199411000-00009
  10. Harrison MJ, Eisenberg MB, Ullman JS, Oppenheim JS, Camins MB, Post KD : Symptomatic cavernous malformations affecting the spine and spinal cord. Neurosurgery 37 : 195-204; discussion 204-205, 1995 https://doi.org/10.1227/00006123-199508000-00002
  11. Lee KS, Spetzler RF : Spinal cord cavernous malformation in a patient with familial intracranial cavernous malformations. Neurosurgery 26 : 877-880, 1990 https://doi.org/10.1227/00006123-199005000-00025
  12. Maraire JN, Awad IA : Intracranial cavernous malformations : lesion behavior and management strategies. Neurosurgery 37 : 591-605, 1995 https://doi.org/10.1227/00006123-199510000-00001
  13. Marchuk DA, Gallione CJ, Morrison LA, Clericuzio CL, Hart BL, Kosofsky BE, et al : A locus for cerebral cavernous malformations maps to chromosome 7q in two families. Genomics 28 : 311-314, 1995 https://doi.org/10.1006/geno.1995.1147
  14. McCormick P, Michelsen W : Management of intracranial cavernous and venous malformations, in Barrow DL (ed) : Intracranial Vascular Malformations. Park Ridge, AANS PP 197-217, 1990
  15. Narayan P, Barrow DL : Intramedullary spinal cavernous malformation following spinal irradiation. Case report and review of the literature. J Neurosurg 98 (Suppl 1) : 68-72, 2003
  16. Ogilvy CS, Louis DN, Ojemann RG : Intramedullary cavernous angiomas of the spinal cord : clinical presentation, pathological features, and surgical management. Neurosurgery 31 : 219-229; discussion 229-230, 1992 https://doi.org/10.1227/00006123-199208000-00007
  17. Rigamonti D, Hadley MN, Drayer BP, Johnson PC, Hoenig-Rigamonti K, Knight JT, et al : Cerebral cavernous malformations. Incidence and familial occurrence. N Engl J Med 319 : 343-347, 1988 https://doi.org/10.1056/NEJM198808113190605
  18. Sandalcioglu IE, Wiedemayer H, Gasser T, Asgari S, Engelhorn T, Stolke D : Intramedullary spinal cord cavernous malformations : clinical features and risk of hemorrhage. Neurosurg Rev 26 : 253- 256, 2003 https://doi.org/10.1007/s10143-003-0260-2
  19. Santoro A, Piccirilli M, Frati A, Salvati M, Innocenzi G, Ricci G, et al : Intramedullary spinal cord cavernous malformations : report of ten new cases. Neurosurg Rev 27 : 93-98, 2004 https://doi.org/10.1007/s10143-003-0302-9
  20. Spetzler RF, Detwiler PW, Riina HA, Porter RW : Modified classification of spinal cord vascular lesions. J Neurosurg 96 : 145-156, 2002
  21. Vaquero J, Martinez R, Martinez P : Cavernomas of the spinal cord : report of two cases. Neurosurgery 22 : 143-144, 1988 https://doi.org/10.1227/00006123-198801000-00025
  22. Vishteh AG, Sankhla S, Anson JA, Zabramski JM, Spetzler RF : Surgical resection of intramedullary spinal cord cavernous malformations : delayed complications, long-term outcomes, and association with cryptic venous malformations. Neurosurgery 41 : 1094-1100; discussion 1100-1101, 1997 https://doi.org/10.1097/00006123-199711000-00013
  23. Vishteh AG, Zabramski JM, Spetzler RF : Patients with spinal cord cavernous malformations are at an increased risk for multiple neuraxis cavernous malformations. Neurosurgery 45 : 30-32; discussion 33, 1999 https://doi.org/10.1097/00006123-199907000-00008
  24. Zabramski JM, Wascher TM, Spetzler RF, Johnson B, Golfinos J, Drayer BP, et al : The natural history of familial cavernous malformations : results of an ongoing study. J Neurosurg 80 : 422-432, 1994 https://doi.org/10.3171/jns.1994.80.3.0422
  25. Zevgaridis D, Medele RJ, Hamburger C, Steiger HJ, Reulen HJ : Cavernous haemangiomas of the spinal cord. A review of 117 cases. Acta Neurochir (Wien) 141 : 237-245, 1999 https://doi.org/10.1007/s007010050293