The Study of Emulsion System Containing with Perfluorinated Compounds (PFCs)

Perfluorinated Compounds (PFCs) 안정화 시스템의 연구

  • Choi, Bong-Ki (Skin Care R&D Center of Skin Science and Cosmetics, Enprani Co., Ltd.) ;
  • Cho, Hee-Won (Skin Care R&D Center of Skin Science and Cosmetics, Enprani Co., Ltd.) ;
  • Kim, Hyo-Jung (Skin Care R&D Center of Skin Science and Cosmetics, Enprani Co., Ltd.) ;
  • Lee, Joo-Dong (Skin Care R&D Center of Skin Science and Cosmetics, Enprani Co., Ltd.)
  • 최봉기 ((주) 엔프라니 피부과학연구소) ;
  • 조희원 ((주) 엔프라니 피부과학연구소) ;
  • 김효정 ((주) 엔프라니 피부과학연구소) ;
  • 이주동 ((주) 엔프라니 피부과학연구소)
  • Published : 2007.12.30

Abstract

When Perfluorinated Compounds (PFCs) are applied in cosmetic products, they have many merits because of unique feeling and characters. However, it is very difficult to use them as cosmetic ingredients because they are insoluble material in oil and water and have high specific gravity. To develop a special system to stabilize PFCs in cosmetic products, we compared three systems, of gel network system, spherulite lamellar system, and nanostructure system. We found that nanostructure system was the optical system for stabilizing PFCs.

PFCs는 독특한 사용감과 특성으로 인하여 화장품에 응용되어질 때 많은 특장점을 가지고 있다. 그러나 이러한 장점에도 불구하고 화장품 제형에 적용하기에 많은 어려움을 가지고 있다. 즉, 물과 오일에 불용성, 높은 비중, 높은 증기압 등과 같은 원료의 특징으로 인하여 PFCs는 화장품에 적용하기 위하여 특별한 안정화 시스템을 필요로 한다. 본 연구에서 PFCs를 안정화하기 위하여 gel network, spherulite lamellar, nanostructure 이상의 세 가지 시스템을 이용하였으며 사용된 세 가지 시스템 중 nanostructure system이 가장 안정함을 알 수 있었다.

Keywords

References

  1. G. Malinvemo, G. Pantini, and J. Bootman, Safety evaluation of perfluoro polyethers: liquid polymers used in barrier creams and other skincare products, Food Chem. Toxicol., 34, 639 (1996) https://doi.org/10.1016/0278-6915(96)00023-3
  2. G. Pantini, R. Forestieri, F. Brunetta, and P. L. Bencini, Treatment of irritant contact dermatitis in workmen with perfluoropolymethylisopropyl ether, Int. J. cosmetic Sci., 12(6), 273 (1990) https://doi.org/10.1111/j.1467-2494.1990.tb00542.x
  3. C. Crosti, P. L. Bencini, F. Brunetta, and G. Pantini, Perfluoropoly ethers (Fomblin HC) for treatment of chronic irritant dermatitis of the dermatitis controlled study, SOFW Journal, 16, 1020 (1990)
  4. P. L. Bencini, A. Lodi, G. Chiarelli, C. Crosti, and G. Pantini, Creams for treatment of chronic irritant dermatitis, Drug Cosmet. Lnd., 28 (1990)
  5. F. Pasquariello, P. L. Bencini, and G. Pantini, The protective effect of a perfluoropolyether against skin irritation caused by aqueous vapours containing hydrogen sulphide, Hospital Management, 14 (1992)
  6. G. Pantini, Perfluoropolyethers: status and new developments, Cosmetics & Toiletes, 106(10), 71 (1991)
  7. P. Simard, D. Hoarau, M. N. Khalid, E. Roux, and J. C. Leroux, Preparation and in vivo evaluation of PEGylated spherulite formulations, Biochimica et Biophysica Acta., 1715, 37 (2005) https://doi.org/10.1016/j.bbamem.2005.06.013
  8. C. M. Douaihy, V. Koka, C. Mingotaud, and F. Gauffre, Tunable sustained release properties of 'onion-like' phospholipids multilamellar vesicles, J. Colloid Interface Sci., 303, 280 (2006) https://doi.org/10.1016/j.jcis.2006.07.085
  9. R. H. Muller, M. Radtke, and S. A. Wissing, Solid lipid nanoparticle (SLN) and nanostuructured lipid carriers (NLC) in cosmetic and dermatological preparations, Adv. Drug Deliv. Rev., 131 (2002)
  10. R. Jimmie and J. Baran, Winsor I⇒II⇒III microemulsion phase behavior of hydrofluoroethers and fluorocarbon/catanionics surfactants, J. Colloid Interface Sci., 234, 117 (2001) https://doi.org/10.1006/jcis.2000.7284