Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Scintigraphic Assessment of Hepatobiliary Functions in Healthy Miniature Pigs

건강한 미니돼지에서 간담도 기능의 핵의학적 평가

  • Kim, Se-Eun (College of Veterinary Medicine, Chonnam National University) ;
  • Shim, Kyung-Mi (College of Veterinary Medicine, Chonnam National University) ;
  • Yoo, Kyeong-Hoon (College of Veterinary Medicine, Chonnam National University) ;
  • Lee, Won-Guk (Department of Nuclear Medicine, College of Medicine, Chungbuk National University) ;
  • Choi, Seok-Hwa (College of Veterinary Medicine, Chungbuk National University) ;
  • Park, Soo-Hyun (College of Veterinary Medicine, Chonnam National University) ;
  • Han, Ho-Jae (College of Veterinary Medicine, Chonnam National University) ;
  • Kang, Seong-Soo (College of Veterinary Medicine, Chonnam National University)
  • Published : 2007.12.31
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Abstract

The purpose of this study is to investigate normal hepatobiliary functions in healthy miniature pigs. $^{99m}Tc-DISIDA$ hepatobiliary scintigraphy(HBS) was used for it. Five mCi dose of $^{99m}Tc-DISIDA$ was injected intravenously into 3 healthy adult miniature pigs, and dynamic images were obtained during 1 hour. $^{99m}Tc-DISIDA$ HBS in a miniature pig was evaluated for 6 variables. A cardiac washout occurred within 1 min in all miniature pigs and radioactivities in the gallbladder were not detected in two miniature pigs. Thus, the initial radioactivity and Tmax of the gallbladder were non-available to identify. Mean Tmax of liver was $8.67{\pm}2.08$ min and initial small intestinal radioactivity was seen at $9.67{\pm}2.52$ min after $^{99m}Tc-DISIDA$ injection. Mean hepatic washout time was not detected in 60 min dynamic images. Therefore, $^{99m}Tc-DISIDA$ HBS is the effective diagnostic method to evaluate the function of hepatocyte and bile flow rate. However, it was not a proper method to evaluate the function of gallbladder, which indicates that an additional study is needed to further specify the reasons for the absence of radioactivities in gallbladder of two miniature pigs.

Keywords

References

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