지구성 운동이 본태성 고혈압 쥐 심장근의 eNOS, ET-1 mRNA와 골격근 eNOS 단백질 발현에 미치는 영향

The Effects of Exercise Training on Cardiac eNOS, ET-1 mRNA and Skeletal Muscle eNOS Protein Level in SHR

12주간의 저강도 트레드밀 운동은 본태성 고혈압 쥐의 안정시 심박수와 혈압, LPOA와 호모시스테인 수준의 개선과 함께 심장근의 eNOS mRNA 및 골격근의 sNOS 단백질 발현량을 증가시킨 반면 심근의 ET-1 mRNA 수준을 감소시키는 것으로 나타났다. 이러한 결과들은 결국 운동이 혈압조절 뿐만 아니라 고혈압에 의한 심근비대현상 관련 유전자들의 기능개선을 가져와 고혈압을 개선시키는 작용을 한다는 것을 확인 할 수 있었다.

In the present study, all of the treadmill exercise-trained SHR expressed clear adaptive changes such as reduced resting heart rate and blood pressures, LPOA, homocysteine Therefore, treadmill exercise was sufficient to induce physiological adaptation in the SHR. Endurance training is known to induce physiological cardiac hypertrophy, while hypertension induces patho logical cardiac hypertrophy that increases cardiomyocyte apoptosis. The pathological adaptation to pressure overload has also been associated with a further increase in the expression of several marker genes including cardiomyocyte ET-1 in the SHR, but not in the exercise-trained SHR. Additionally, there is an increase in the endothelial nitricoxide synthases (eNOS) protein expression of soleus, gastrocnemius, and extensor digitorum longus muscle in the exercise-trained SHR but not in the SHR in the present study. Thus, compared to pathological adaptation to pressure overload, physiological adaptation to exercise training is associated with distinct alterations in cardiac and molecular phenotypes. based on these results, exercise training improves hypertension by cardiovascular regulating genes and hemodynamic parameters.