Antidiabetic Effect of Auricularia auricula Mycelia in Streptozotocin-induced Diabetic Rats

  • Published : 2007.12.31


Auricularia auricula (Heterobasidiae) called 'tree ear' or 'ear mushroom' was investigated to know its antidiabetic effect. Administration of dried powder of Auricularia auricula mycelia (AAM) (0.5 g/kg bw and 1.0 g/kg bw) caused a statistically significant reduction of plasma glucose (35% and 39%, respectively), total cholesterol (18% and 22%, respectively), triglyceride (12% and 13%, respectively), GOT (53% and 56%, respectively) GPT (26% and 37%, respectively), levels and the rate of liver weight against final total body weight (6% and 7%, respectively) compared with diabetic control group. These results support the antidiabetic effect of AAM.



  1. Acharya, K., Samui, K., Rai, M., Dutta, B.B., and Acharya, R., Antioxidant and nitric oxide synthase activation properties of Auricularia auricula. Indian J. Exp. Biol., 42, 538-540 (2004)
  2. Bierman, E.L., George Lyman Duff Memorial Lecture. Atherogenesis in diabetes. Arterioscler. Thromb., 12, 647-656 (1992)
  3. Chang, J.S., Kim, H.J., Bae, J.T., Park, S.H., Lee, S.E., Kim, O.M., and Lee, K.R., Inhibition effects of Auricularia auricula–judae methanol extract on lipid peroxidation and liver damage in benzopyrene-treated mice. J. Korean Soc. Food Sci. Nutr., 27, 712-717 (1998)
  4. Fan, L., Zhang, S., Yu, L., and Ma, L., Evaluation of antioxidant property and quality of breads containing Auricularia auricula polysaccharide flour. Food Chem., 101, 1158-1163 (2006)
  5. Finkel, T. and Holbrook, N.J., Oxidants, oxidative stress and the biology of aging, Nature, 408, 239-247 (2000)
  6. Grag, A. and Grundy, S.M., Management of dyslipidemia in NIDDM. Diabetes Care, 13, 153-169 (1990)
  7. Gray, A.M. and Flatt, P.R., Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom). J. Endocrinol., 157, 259-266 (1998)
  8. Han, B.H., Norio, A., Kin, F.C., Guo, W.Q., and Fumin, Z., International collation of traditional and folk medicine. World Scientific Publishing, Singapore, 3, 7-8 (1997)
  9. Jung, U.J., Baek, N.I., Chung, H.G., Yoo, M.H., Jeong, T.S., Lee, K.T., Kang, Y.J., Lee, M.K., Kim, H.J., Yeo, J.Y., and Choi, M.S., The antidiabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice. Food Chem. Toxicol., 45, 2022-2029 (2007)
  10. Kakuda, T., Sakane, I., Takihara, T., Ozaki, Y., Takeuchi, H., and Kuroyanagi, M., Hypoglycemic effect of extracts from Lagerstroemia speciosa L. leaves in genetically diabetic KK-Ay mice. Biosci. Biotechnol. Biochem., 60, 204-208 (1996)
  11. Kato, A. and Miura, T., Hypoglycemic action of rhizomes of Polygonatum officinale in normal and diabetic mice. Planta Med., 60, 201-203 (1994)
  12. Kim, T.I., Park, S.J., Choi, C.H., Lee, S.K. and Kim, W.H., Effect of ear mushroom (Auricularia) on functional constipation. The Korean Journal of Gastroenterolgy, 44, 34-41 (2004)
  13. Kwon, Y.M., Cho, S.M., Kin, J.H., Lee, J.H., Lee, Y.A., Lee, S.J., and Lee, M.W., Hypoglycemic Effect of Cordyceps militaris. Kor. J. Pharmacogn., 32, 327-329 (2001)
  14. Lee, M.W., Kim, J.S., Cho, S.M., Kim, J.H., and Lee, J.S., Anti-diabetic Constituent from the Node of Lotus Rhizome (Nelumbo nucifera Gaertn). Nat. Prod. Sci., 7, 107-109 (2001)
  15. Li, S.P., Zhang, G.H., Zeng, Q., Huang, Z.G., Wang, Y.T., Dong, T.T., and Tsim, K.W., Hypoglycemic activity of polysaccharide, with antioxidation, isolated from cultured Cordyceps mycelia. Phytomedicine, 13, 428-433 (2006)
  16. Lo, H.C., Hsu, T.H., Tu, S.T., and Lin, K.C., Anti-hyperglycemic activity of natural and fermented Cordyceps sinensis in rats with diabetes induced by nicotinamide and streptozotocin. Am. J. Chin. Med., 34, 819-832 (2006)
  17. Mendola, J., Wright, J.R., and Lacy, P.E., Oxygen free radical scavenger and immune destruction of murine low-dose STZ-induced insulitis. Diabetes, 38, 379-385 (1989)
  18. Pisuena, M.E., Mojica, E.R.E., and Merca, F.E., Isolation and partial characterization of non-blood specific lectins from Auricularia auricula (Hook) Underw. and Polyporus sp. Asia Life Science, 12, 97- 110 (2003)
  19. Takasu, N., Komiya, I., and Asawa, T., STZ and alloxan-induced $H_2O_2$ generation and DNA fragmentation in pancreatic islet. Diabetes, 40, 1141-1145 (1991)
  20. Takeujchi, H., He, P., and Mooi, L.Y., Reductive effect of hot-water extracts from woody ear (Auricularia auricula-judae Quel.) on food intake and blood glucose concentration in generally diabetic KK-Ay mice. J. Nutr. Sci. Vitaminol., 50, 300-3004 (2004)
  21. Taylor, S.I., Deconstructing type 2 diabetes. Cell, 97, 9-12 (1999)
  22. Yang, B.K., Kim, D.H., Jeong, S.C., Das, S., Choi, Y.S., Shin, J.S., Lee, S.C., and Song, C.H., Hypoglycemic effect of a Lentinus edodes exopolymer produced from a submerged mycelial culture. Biosci. Biotechnol. Biochem., 66, 937-42 (2002)
  23. Yang, K., Jeong, S.C., Lee, H.J., Sohn, D.H., and Song, C.H., Antidiabetic and hypolipidemic effects of Collybia confluens mycelia produced by submerged culture in streptozotocin-diabetic rats. Arch. Pharm. Res., 29, 73-79 (2006)
  24. Yoon, S.J., Yu, M.A., Pyun, Y.R., Hwang, J.K., Chu, D.C., Juneja, L.R., and Mourao, P.A., The nontoxic mushroom Auricularia auricula contains a pokysaccharide with anticoagulant activity mediated by antithrombin. Thromb. Res., 112, 151-158 (2003)
  25. Zhang, L., Yang, L., Qiong, D., and Chen, X., Studies on molecular weights of polysaccharides of Auricularia auricula-judae. Carbohydr. Res., 270, 1-10 (1995)
  26. Zhang, G., Huang, Y., Bian, Y., Wong, J.H., Ng, T.B., and Wang, H., Hypoglycemic activity of the fungi Cordyceps militaris, Cordyceps sinensis, Tricholoma mongolicum, and Omphalia lapidescens in streptozotocin-induced diabetic rats. Appl. Micorbiol. Biotechnol., 72, 1152-1156 (2006)