Natural Product Sciences

  • 제13권4호
  • /
  • Pages.283-288
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  • 2007
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Immunostimulatory effect of Korean traditional medicine Acanthopanacis Cortex

  • Chang, In-Ae (Department of Infection Biology, Zoonosis Research Center, School of Medicine Wonkwang University) ;
  • Shin, Hye-Young (Department of Infection Biology, Zoonosis Research Center, School of Medicine Wonkwang University) ;
  • Kim, Youn-Chul (College of pharmacy, Wonkwang University) ;
  • Yun, Yong-Gab (Department of Oriental Medicine, Wonkwang University) ;
  • Park, Hyun (Department of Infection Biology, Zoonosis Research Center, School of Medicine Wonkwang University)
  • 발행 : 2007.12.31
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초록

Acanthopanacis Cortex (AC) has been popularly used as an herbal medicine for medical treatment of rheumatoid arthritis, insomnia, impotence and diabetes. Here, we investigated immunostimulating effects of the aqueous extract of AC on macrophage. We studied nitric oxide (NO) and tumor necrosis factor (TNF)-${\alpha}$ release in response to AC treatment, as they are important secretory products of macrophage. AC alone induce the NO and TNF-${\alpha}$ production. AC increase c-Jun NH2-terminal kinase 1/2 (JNK) and extracellular signal-regulated kinase (ERK) phosphorylation but does not p38 activation in RAW 264.7 cells. Also AC resulted in the enhanced cell-surface expression of CD80 and CD14. In addition, AC resulted in enhanced T cell-stimulatory capacity and increased T cell secretion of interferon (IFN)-gamma. After feeding with AC to mouse for 10 days, the change of $CD28^+$ and $CD40^+$ population was analyzed. AC increased $CD28^+$ population in splenocytes in vivo. These studies indicate that AC induces macrophage activation and suggest the possible use of AC in macrophage-based immunotherapies.

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