Treatment of natural tropical theileriosis with the extract of the plant Peganum harmala

  • Mirzaei, Mohammad (Department of Pathobiology, School of Veterinary Medicine, Shahid Bahonar University of Kerman)
  • Published : 2007.12.31

Abstract

Theileria annulata, a protozoan parasite of cattle and domestic buffaloes, is transmitted by ticks of the genus Hyalomma, and causes a disease named Mediterranean or tropical theileriosis. In this research 50 cattle naturally infected with Theileria annulata were treated with the extract of the plant Peganum harmala. The treatment was continued for 5 days, the dose of the extract being 5 mg/kg per day. After the treatment, 39 cattle responded to the treatment and recovered, but 11 did not respond to the treatment and died. The recovery rate of animals treated with the extract of the plant Peganum harmala was 78%.

Keywords

References

  1. Budavari S, O'neil MJ (1996) The Merk Index, 12nd ed. pp 4644-4645, CRC Press, New Jersey, USA
  2. Fan B, Liang J, Men J, Gao F, Li G, Zhao S, Hu T, Dang P, Zhang L (1997) Effect of total alkaloid of Peganum harmala L. in the treatment of experimental haemosporidian infections in cattle. Trop Anim Health Prod 29(4, suppl.): 77S-83S https://doi.org/10.1007/BF02632322
  3. Hamburger M, Hostettmann K (1991) Bioactivity in plants: the link between phytochemistry and medicine. Phytochemistry 30: 3864-3874 https://doi.org/10.1016/0031-9422(91)83425-K
  4. Hashemi-Fesharki R (1991) Chemotherapeutic value of parvaquone and buparvaquone against Theileria annulata infection of cattle. Res Vet Sci 50: 204-207 https://doi.org/10.1016/0034-5288(91)90107-Y
  5. Hu T, Fan B, Liang J, Zhao S, Dang P, Gao F, Dong M (1997) Observations on the treatment of natural haemosporidian infections by total alkaloid of Peganum harmala L. in cattle. Trop Anim Health Prod 29(4, suppl.): 72S-76S https://doi.org/10.1007/BF02632936
  6. Kamel S, Ibrahim L, Afifi A, Hamza S (1970) Major alkaloidal constituents of the Egyptian plant, Peganum harmala. UAR J Vet Sci 7: 71-86
  7. Lala S, Pramanick S, Mukhopadhyay S, Bandyopadhyay S, Basu MK (2004) Harmine: evaluation of its antileishmanial properties in various vesicular delivery systems. J Drug Target 12: 165-175 https://doi.org/10.1080/10611860410001712696
  8. Manske RHF, Holmes HL (1952) The Alkaloids: Chemistry and Pharmacology. p 393, Academic Press, New York, USA
  9. Mbwambo HA, Sudi FF, Mkonyi PA, Mfinanga JM, Mella ES, Ngovi CJ (2002) Comparative studies of the efficacy of parvaquone and parvaquone-plus-frusemide in the treatment of Theileria parva infection (East Coast fever) in cattle. Vet Parasitol 108: 195-205 https://doi.org/10.1016/S0304-4017(02)00195-4
  10. McHardy N, Wekesa LS, Hudson AT, Randall AW (1985) Antitheilerial activity of BW720C (buparvaquone): a comparison with parvaquone. Res Vet Sci 39: 29-33
  11. Mirzaiedehaghi M (2006) Treatment of natural ovine malignant theileriosis with a chloroform extract of the plant Peganum harmala. Onderstepoort J Vet Res 73: 153-155
  12. Purnell RE (1978) Theileria annulata as a hazard to cattle in countries on the northern Mediterranean littoral. Vet Sci Commun 2: 3-10 https://doi.org/10.1007/BF02291428
  13. Puzii AD, Serov VM (1983) Persistence of pegarmin (a preparation of the alkaloids of Peganum harmala) in the body (of cattle) Veterinariia No. 5, 62-64
  14. Puzii AD, Vecherkin SS, Toptaev VI, Tsyganova GA, Duisheev NA (1982) Tests for teratogenic and embryotoxic properties of pegarmin (alkaloid of the plant Peganum) and its therapeutic use in cattle infected with Theileria annulata. Trudy Vsesoyuznogo Instituta Eksperimental'noi Veterinarii 56: 31-38
  15. Vecherkin SS, Puzii AD, Romakhov VG, Tribunskii MP (1977) Harmal alkaloids in theileriasis. Veterinariia No. 10, 77-78
  16. Wright CW, Phillipson JD (1990) Natural products and the development of selective antiprotozoal drugs. Phytother