Cigarette Smoking and Gastric Cancer Risk in a Community-based Cohort Study in Korea

흡연과 위암 발생의 관련성에 관한 지역사회 기반의 코호트 연구

  • Kim, Yeon-Ju (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Shin, Ae-Sun (Division of Cancer Prevention, National Cancer Control Research Institute, National Cancer Center) ;
  • Gwack, Jin (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Jun, Jae-Kwan (Division of Cancer Prevention, National Cancer Control Research Institute, National Cancer Center) ;
  • Park, Sue-Kyung (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Kang, Dae-Hee (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Shin, Hai-Rim (Division of Cancer Prevention, National Cancer Control Research Institute, National Cancer Center) ;
  • Chang, Soung-Hoon (Department of Preventive Medicine, Konkuk University College of Medicine) ;
  • Yoo, Keun-Young (Department of Preventive Medicine, Seoul National University College of Medicine)
  • 김연주 (서울대학교 의과대학 예방의학교실) ;
  • 신애선 (국립암센터 국가암관리사업단 암예방사업부) ;
  • 곽진 (서울대학교 의과대학 예방의학교실) ;
  • 전재관 (국립암센터 국가암관리사업단 암예방사업부) ;
  • 박수경 (서울대학교 의과대학 예방의학교실) ;
  • 강대희 (서울대학교 의과대학 예방의학교실) ;
  • 신해림 (국립암센터 국가암관리사업단 암예방사업부) ;
  • 장성훈 (건국대학교 의과대학 예방의학교실) ;
  • 유근영 (서울대학교 의과대학 예방의학교실)
  • Published : 2007.11.30

Abstract

Objectives : Gastric cancer is the most common incident cancer in Korea. Although Helicobacter pylori infection is the most important risk factor for the development of gastric cancer, cigarette smoking has also been suggested to play an important role in the development of gastric cancer. The objective of this study is to evaluate the relationship between cigarette smoking and gastric cancer risk in a Korean population. Methods : The study population consisted of 13,785 subjects who had been enrolled in the Korean Multi-Center Career Cohort between 1993 and 2002. As of December 2002, 139 incident gastric cancer cases were ascertained through the Korea Central Cancer Registry and the National Death Certificate Database. Relative risks (RR) and 95% confidence intervals (CI) for gastric cancer were estimated using Cox#s proportional hazard model adjusted for age, education, alcohol drinking status and history of gastritis or ulcer. Results : Significant dose-response relationships were observed between the duration of smoking and the risk of gastric cancer among the male subjects in comparison to non-smokers: men who smoked for 20-39 years had a 2.09-fold (95% CI 1.00-4.38) increase, and those who smoked for more than 40 years had a 3.13-fold (95% CI 1.59-6.17) increase in the risk of gastric cancer ($P_{trend}<0.01$). Conclusions : This study suggests that a longer duration of cigarette smoking may increase the risk of gastric cancer development in a dose-response manner in Korean men. The association between smoking and gastric cancer risk in women should be verified in future studies with a larger number of cases.

Keywords

References

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