생명과학회지 (Journal of Life Science)

  • 제17권10호
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  • Pages.1387-1393
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  • 2007
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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STZ 및 고지방식이에 의해 유도된 흰쥐의 고혈당 및 고지혈에 대한 함박잎새버섯분말의 효능

Effects of Hambag Mushroom (Grifola frondosa)-Powder on Hyperglycemia and Hyperlipemia in STZ and High Fat Diet-induced Diabetic Rats

  • 이순이 (아시아대학교 뷰티주얼리디자인학과) ;
  • 박영철 (대구가톨릭대학교 바이오안전성센터) ;
  • 김종봉 (대구가톨릭대학교 자연대학 의생명과학과)
  • 발행 : 2007.10.30
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초록

함박잎새버섯은 잎새버섯의 한 품종으로 농업과학기술원의 야생균주로부터 개량된 새로운 품종이다. 인공재배에 의하여 대량생산이 이루어지고 있다. Streptozotocin와 고지방식이에 의해 유도된 실험쥐 당뇨에 있어서 고혈당 및 고지질 혈에 대한 함박잎새버섯분말의 효능과 부분적인 기전을 6 주간의 사육기간을 통한 결과는 다음과 같다. 1. 함박잎새버섯분말 투여에 의한 체중증가량은 당뇨를 가진 실험쥐의 2 배로 분말이 당뇨에 의해 유도된 체중감소의 병폐현상을 막아주는 주는 역할을 하는 것으로 추정된다. 2. 함박잎새버섯분말 투여는 혈당을 약 200 mg/dl 정도 감소한 당뇨를 가진 실험쥐 혈당의 약 50% 수준이었다. 3. 당뇨 유발에 의해 증가된 Triglyceride, 총콜레스테롤, LDL-cholesterol의 함량은 함박잎새버섯분말 투여에 의해 용량-의존성 경향을 보이면서 감소되었다. 그러나 당뇨 유발에 의해 감소된 HDL-cholesterol 함량은 함박잎새버섯분말 투여에 의해 증가되었다. 4. 함박잎새버섯분말 투여에 의한 당뇨-유도성 췌장 손상정도가 감소하였으며 이러한 효능이 당뇨 유발 실험쥐에 있어서 고혈당과 고혈지질을 조절하는 부분적인 기전으로 이해된다.

Hambag mushroom is edible mushroom, and one of new strains in Grifola frondosa. It was developed from Korean wild Grifola frondosa by National Institute Science & Technology. In this study, we investigated the effects of the powder extracted from fruit-body of hambag mushroom on hyperglycemia, hyperlipemia and pancreatic cells in rats with streptozotocin (STZ) and high fat diet-induced diabetes. The diabetic rats were fed with hambag mushroom-powder (1 and 2% of diet weight) for 6 weeks. And then the levels of blood glucose and lipid and the pancreatic tissue were analyzed and compared. The diabetic rats fed with hambag mushroom-powder lost less body weight than those fed with the powder-free normal diet. flood glucose levels in the diabetic rats fed with hambag mushroom-powder at all concentrations was lower by 50% than in the diabetic rats fed with normal diet. The levels of total cholesterol, triglyceride and LDL-cholesterol in the diabetic rats fed with hambag mushroom-powder were increased compared to those in the diabetic rats fed with normal diet. There were the blood levels of cholesterol, triglyceride and LDL-cholesterol by hambag mushroom-powder concentrations in a dose-dependent response. The decreased damage of pancreatic tissue in the group treated with hambag mushroom-powder could be suggested possibly as one of mechanisms for the effects of hambag mushroom-powder on hyperglycemia and hyperlipemia.

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  1. Inhibition of α-Glucosidase by a Semi-Purified Ethyl Acetate Fraction from Submerged-Liquid Culture of Agaricus blazei Murill vol.21, pp.11, 2011, https://doi.org/10.5352/JLS.2011.21.11.1579
  2. Effects of Medicinal Plant Water Extracts on Expression of Anti-diabetic Enzymes mRNA vol.42, pp.7, 2013, https://doi.org/10.3746/jkfn.2013.42.7.1008