Journal of the Korean Academy of Child and Adolescent Psychiatry

Korean Academy of Child and Adolescent Psychiatry (대한소아청소년정신의학회)
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No Association of DRD4 Exon III Polymorphism with Attention-Deficit Hyperactivity Disorder in Korean Children Population

도파민 소용체 제4형 Exon III 다형성과 주의력결핍 과잉운동장애의 연합연구

  • Cho, Soo-Churl (Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Park, Tae-Won (Department of Psychiatry, College of Medicine, Chonbuk National University) ;
  • Kim, Jae-Won (Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Yoo, Hee-Jeong (Department of Neuropsychiatry, Seoul National University College of Medicine, Seoul National University Bungdang Hospital) ;
  • Kim, Boong-Nyun (Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Shin, Min-Sup (Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Hwang, Jun-Won (Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University Hospital)
  • 조수철 (서울대학교 신경정신과 소아청소년분과) ;
  • 박태원 (전북대학교 의과대학 정신과학교실) ;
  • 김재원 (서울대학교 신경정신과 소아청소년분과) ;
  • 유희정 (서울대학교 의과대학 분당서울대학교병원 정신과학교실) ;
  • 김붕년 (서울대학교 신경정신과 소아청소년분과) ;
  • 신민섭 (서울대학교 신경정신과 소아청소년분과) ;
  • 황준원 (서울대학교 신경정신과 소아청소년분과)
  • Published : 2007.10.30
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Abstract

Objectives: The aim of the current study is to test for the association of DRD4 exon III VNTR polymorphism with attention-deficit hyperactivity disorder(ADHD) in Korean children population. Methods: 113 Korean children with ADHD, 102 parents, and 133 control subjects participated with the current study. The distribution of genotypes and alleles of DRD4 exon III VNTR in children with ADHD was compared with that in control subjects. In addition, 69 children with ADHD and their parents were analyzed using the transmission disequilibrium test(TDT). Results: We could not find any significant differences in the distribution of genotypes and alleles at DRD4 exon III VNTR polymorphism between children with ADHD and control subjects. In addition, there was no preferential transmission of long allele of DRD4 exon III VNTR polymorphism. Conclusion: These results suggest that DRD4 is not associated with ADHD in Korean children population.

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