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Cyanosilylation of Carbonyl Compounds Catalyzed by Potassium L-Aspartate

  • George, Soney C. (Department of Chemistry, Inha University) ;
  • Kim, Sung-Soo (Department of Chemistry, Inha University) ;
  • Kim, Ho-Sub (Department of Chemistry, Inha University)
  • Published : 2007.12.20
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Abstract

Potassium L-aspartate has been used as a catalyst for the cyanosilylation of carbonyl compounds producing corresponding cyanohydrin trimethylsilyl ethers in excellent yield of up to 98%. Although the catalyst is chiral, the enantioselectivities observed are generally poor except for one case, α-naphthaldehyde, 89% ee.

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References

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