Bulletin of the Korean Chemical Society

  • 제28권12호
  • /
  • Pages.2235-2240
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  • 2007
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Design, Synthesis and Biological Activity of Certain 3,4-Disubstituted-5-mercapto-1,2,4-triazoles and Their Hydrazino Derivatives

  • Udupi, R.H. (Department of Pharmaceutical Chemistry, N.E.T. Pharmacy College) ;
  • Sudheendra, Sudheendra (Department of Pharmaceutical Chemistry, N.E.T. Pharmacy College) ;
  • Bheemachari, Bheemachari (Department of Pharmaceutical Chemistry, N.E.T. Pharmacy College) ;
  • Srinivasulu, N. (Department of Pharmaceutical Chemistry, N.E.T. Pharmacy College) ;
  • Varnekar, Rajesh (Department of Pharmaceutical Chemistry, N.E.T. Pharmacy College) ;
  • Purushottamachar, Puranik (Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine)
  • 발행 : 2007.12.20
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초록

3-Aryloxy methyl-4-(N-pyrazin-2'yl carboxamido)-5-mercapto-1,2,4-triazoles (3a1-a14) were prepared starting from potassium dithio carbazinates (2a1-a14). These triazoles were then employed in the synthesis of 3-aryloxy methyl-4-(N-pyrazin-2'yl carboxamido)-5-hydrazino-1,2,4-triazoles (4a1-a14). All the newly synthesized compounds were characterized by analytical, IR, NMR spectral studies. The compounds were screened for their antibacterial, antifungal, anti-inflammatory and analgesic properties. Most of the compounds have shown significant antifungal activity while few have shown excellent anti-inflammatory and analgesic activity. An attempt is made to study the structure activity relationship (SAR).

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참고문헌

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  3. ChemInform Abstract: Design, Synthesis and Biological Activity of Certain 3,4-Disubstituted-5-mercapto-1,2,4-triazoles and Their Hydrazino Derivatives. vol.39, pp.18, 2008, https://doi.org/10.1002/chin.200818125
  4. Synthesis, characterization and photophysical studies of a novel schiff base bearing 1, 2, 4-Triazole scaffold vol.1113, pp.None, 2007, https://doi.org/10.1016/j.molstruc.2016.02.036