Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Anti-arthritic effect of radix Paeoniae rubra herb-acupuncture: a behavioral evaluation on adjuvant-induced arthritis rats

  • Kim, Seung-Tae (Acupuncture & Meridian Science Research Center, Kyung-Hee University) ;
  • Hahm, Dae-Hyun (Acupuncture & Meridian Science Research Center, Kyung-Hee University) ;
  • Kim, Gun-Ho (Acupuncture & Meridian Science Research Center, Kyung-Hee University) ;
  • Park, Jong-Bae (Acupuncture & Meridian Science Research Center, Kyung-Hee University) ;
  • Han, Dong-Oh (Acupuncture & Meridian Science Research Center, Kyung-Hee University) ;
  • Park, Hi-Joon (Acupuncture & Meridian Science Research Center, Kyung-Hee University) ;
  • Shim, In-Sop (Department of Integrative Medicine, College of Medicine, The Catholic University of Korea) ;
  • Park, Hee-Myung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Ki-Hyun (College of Oriental Medicine, Dongkuk University) ;
  • Kim, Jang-Hyun (College of Oriental Medicine, Dongkuk University) ;
  • Choi, Seong-Hun (College of Oriental Medicine, Dongkuk University) ;
  • Lee, Hye-Jung (Acupuncture & Meridian Science Research Center, Kyung-Hee University)
  • Published : 2007.12.31
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Abstract

Radix Paeoniae rubra (PR) has been widely used for recovering acute inflammation with swelling and pain in Far East Asian countries. In order to investigate the anti-arthritic effect of PR herbacupuncture, several behavioral parameters such as body weight, knee circumference, squeaking threshold, and weight distribution ratio were investigated in an adjuvant-induced mono-arthritis rat model. We performed PR herb-acupuncture on Zusanli (ST36) of the right hind-leg once every second day for a total of 6 times from the second day of initiating arthritis with adjuvant injection, while the control group was treated with saline in the same way. In the experimental group, body weight significantly increased, knee circumference and squeaking threshold significantly decreased indicating the reduction of edema, and both the pain and inflammatory swelling of the hind paws measured by incapacitance meter decreased. Conclusively, PR herb-acupuncture has more promising effect in alleviating arthritic pain and inflammation than saline-acupuncture in rat model, hence further clinical study is required.

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