대한본초학회지 (The Korea Journal of Herbology)

  • 제21권4호
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  • Pages.133-141
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  • 2006
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지

인삼산사복합방(人蔘山査複合方)이 Alzheimer성 치매와 관련된 유전자 발현(發顯)에 미치는 영향

Effects of Ginseng Radix plus Crataegi Fructus on the Gene Expression in Relation to Alzheimer's Disease.

  • 한신희 (중부대학교 한방건강관리학과) ;
  • 길기정 (중부대학교 한약자원학과)
  • Han, Sin-Hee (Dept. of Oriental Health Care, Joongbu University) ;
  • Kil, Gi-Jung (Dept. of Oriental Medicine Resources, Joongbu University)
  • 발행 : 2006.12.30
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초록

Objectives : This research was investigated the effect of the Ginseng Radix plus Crataegi Fructus on the gene expression in relation to Alzheimer's disease. Methods : Observed gene expression of the Ginseng Radix plus Crataegi Fructus extract on $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, COX-2, and NOS-II mRNA of BV2 microglia cell line treated with lipopolysacchride. Results : The Ginseng Radix plus Crataegi Fructus extract suppressed the gene expression of $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, COX-2, NOS-II mRNA in BV2 microglia cell line treated with lipopolysacchride. Conclusion : These results suggest that the Ginseng Radix plus Crataegi Fructus extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the Ginseng Radix plus Crataegi Fructus extract for Alzheimer's disease is suggested for future research.

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