대한본초학회지 (The Korea Journal of Herbology)
- 제21권3호
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- Pages.103-109
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- 2006
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
TLR-4 로 유도한 동물 복강 대식세포에서 창이자 추출물의 NO 합성과 $IkB-{\alpha}$ 분해 억제에 의한 염증 반응 억제 효과
Extrat of Xanthii Fructus down-regulate TLR-4 mediated murine peritoneal macrophage inflammatory response by limiting NO synthase and $IkB-{\alpha}$ degradation
- 정원석 (원광대학교 한의과대학 본초학 교실) ;
- 서상완 (원광대학교 한의과대학 본초학 교실) ;
- 조준기 (원광대학교 익산 한방병원) ;
- 손지우 (원광대학교 익산 한방병원) ;
- 박민철 (원광대학교 익산 한방병원) ;
- 최창민 (원광대학교 광주 한방병원) ;
- 염승룡 (원광대학교 광주 한방병원) ;
- 황상욱 (원광대학교 한의과대학 본초학 교실) ;
- 김영우 (원광대학교 한의과대학 본초학 교실) ;
- 송달수 (원광대학교 한의과대학 본초학 교실) ;
- 채영석 (원광대학교 한의과대학 본초학 교실) ;
- 최원석 (원광대학교 한의과대학 본초학 교실) ;
- 노정은 (원광대학교 한의과대학 본초학 교실) ;
- 윤한룡 (원광대학교 한의과대학 본초학 교실) ;
- 김영목 (원광대학교 한의과대학 한방 병리학 교실) ;
- 박성주 (원광대학교 한의과대학 본초학 교실) ;
- 신민교 (원광대학교 한의과대학 본초학 교실) ;
- 송호준 (원광대학교 한의과대학 본초학 교실)
- Jung, Won-Seok (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Seo, Sang-Wan (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Cho, Joon-Ji (Dept. of Internal Medicine, IKsan Oriental Hospital, Wonkwang University) ;
- Son, Ji-Woo (Dept. of Internal Medicine, IKsan Oriental Hospital, Wonkwang University) ;
- Park, Min-Cheol (Dept. of Internal Medicine, IKsan Oriental Hospital, Wonkwang University) ;
- Choi, Chang-Min (Dept. of Internal Medicine, Kwangju Oriental Hospital, Wonkwang University) ;
- Yeom, Seung-Ryong (Dept. of Internal Medicine, Kwangju Oriental Hospital, Wonkwang University) ;
- Hwang, Sang-Wook (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Kim, Yong-Woo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Song, Dal-Soo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Chae, Young-Seok (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Choi, Won-Seok (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- No, Jeong-Eun (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Yun, Han-Ryoung (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Kim, Yeong-Mok (Dept. of Oriental Pathology, College of Oriental Medicine, Wonkwang University) ;
- Park, Sung-Joo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Shin, Min-Kyo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Song, Ho-Jon (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
- 발행 : 2006.09.30
초록
Objectives : The purpose of this study was to investigate the TLR-4 mediated anti-inflammatory effects of extract from Xanthii Fructus(XF) on the peritoneal macrophage. Methods : To evaluate of TLR-4 mediated inflammatory of XF, we examined NO and cytokine production in TRL-4 ligand(LPS-lipopolysacchride) induced macrophages. Furthermore, we checked molecular mechanism using western blot. Results : l.Extract from XF reduced LPS-induced Nitric oxide (NO), tumor necrosis factor-a (TNF-a), interleukin (IL)-6 and IL-12 production in peritoneal macrophages 2.Extract from XF itself does not have any cytotoxic effect.XS inhibited degradation of IkBa in the TLR-4 mediated peritoneal macrophages Conclusion : XF down-regulated TLR4 ligand(LPS)-induced NO and cytokine productions.