Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Antioxidant and analgesic activity of Clerodendrum visconsum leaf

  • Published : 2006.12.31
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Abstract

The crude ethanolic extract of the leaves of Clerodendrum viscosum (Family: Verbenaceae) was evaluated for its antioxidant and analgesic activities to investigate the scientific basis of the traditional uses. The antioxidant property of the extract was assessed by 1, 1-diphenyl -2- picryl hydrazyl (DPPH) free radical scavenging assay. The extract showed prominent antioxidant activity ($IC_{50}about{\sim}16{\mu}g/ml$) which was comparable to standard drug ascorbic acid ($IC_{50}about{\sim}15{\mu}g/ml$).The extract produced significant (P<0.001) writhing inhibition in acetic acid induced writhing in mice at the dose of 125 mg, 250 mg and 500 mg/kg body weight respectively, which were comparable to the standard drug diclofenac sodium. The results tend to suggest that the crude leaves extract at the above doses have antioxidant and analgesic activities and indicate that it might possess biologically active constituents having free radical scavenging and analgesic activities respectably.

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References

  1. Ahmed M, Shikha HA, Sadhu SK, Rahman MT, Datta BK. (2001) Analgesic, Diuretic, and Antiflammatory Principle from Scoparia dulcis. Pharmazie 56, 657-660.
  2. Derardt R, Jougney S, Delevalcee F, Falhout M. (1980) Release of prostaglandins E and F in an algogenic reaction and its inhibition. Eur. J. Pharmacol. 51, 17-24.
  3. Evans WC. (1989) Trease and Evan’s Textbook of Pharmacognosy, 13th ed., Cambridge University Press, London.
  4. Gupta M, Mazumdar UK, Sivahkumar T, Vamis MLM, Karki S, Sambathkumar R, Manikandan L. (2003) Antioxidant and anti-inflammatory activities of Acalypha fruticosa. Nig. J. Nat. Prod. Med. 7, 25-29.
  5. Gani A. (2003) Medicinal Plants of Bangladesh, Chemical Constituents and Uses, p.176. Asiatic Society of Bangladesh, Dhaka.
  6. Hirandra N, Banerjee J. (1936) J. Indian Chem. Soc. 4, 51-57.
  7. Halliwell B, Gutteridge JMC. (1985) In: Free radicals, ageing, and disease, Free radicals in Biology and Medicine, 2nd edition, p. 279-315, Clarendron Press, Oxford.
  8. Halliwell H. (1994) Free radicals, antioxidants, and human disease: Curiosity, cause or consequence? Lancet 344, 721-724. https://doi.org/10.1016/S0140-6736(94)92211-X
  9. JICS (Journal of Indian Chemical Society). (1951) p. 28, 295.
  10. Lork D. (1983) A new approach to acute toxicity testing. Arch. Toxicol. 54, 275-287. https://doi.org/10.1007/BF01234480
  11. Larson RA. (1988) The antioxidants of higher plants. Phytochemistry 27, 969-978. https://doi.org/10.1016/0031-9422(88)80254-1
  12. Meyer. (1982) Phytochemical methods (a guide to modem techniques to plant analysis). 3rd ed. P.335-337, Champan and Hall.
  13. Sen AB, Sing SP. (1964) Ind. J. Chem. 294, 172.
  14. Sinha SKP, Dogra JVV. (1985) Int. J. Crude Drug Res. 23, 77-86.
  15. Sadhu SK, Okuyama E, Fujimoto H, Ishibashi M. (2003) Separation of Leucas aspera, a Medicinal Plant of Bangladesh, Guided by Prostaglandin Inhibitory and Antioxidant Activities. Chem. Pharm. Bull. 51, 595-598. https://doi.org/10.1248/cpb.51.595
  16. Taesotikul T, Panthong A, Kanjanapothi D, Verpoorte R, Scheffer JJC. (2003) Antiinflammatory, antipyretic and antinociceptive activities of Tabernaemontana pandacaqui Poir. J. Ethnopharmacol. 84, 31-35. https://doi.org/10.1016/S0378-8741(02)00264-7
  17. Whittle BA. (1964) The use of changes in capillary permeability in mice to distinguish between narcotic and non-narcotic analgesics. Br. J. Pharmacol. Chemother. 22, 246.

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  1. Pharmacological Evaluation of Bangladeshi Medicinal Plants for Antioxidant Activity vol.46, pp.10-11, 2008, https://doi.org/10.1080/13880200802215735